The Sunday Guardian

Lab leaks of bioweapons are a clear and present danger

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function research (accelerati­ng mutation in viruses to create deadly viruses) and other such dangerous genetic manipulati­ons should be stopped without further delay.

BIO-ENGINEERIN­G ROOTED IN BIO-WARFARE: The first biosafety facility was a cabinet designed in the US in 1943 for United States Army Biological Warfare Laboratori­es, Camp Detrick, Maryland. In the following years, three principal biological warfare laboratori­es of the US Army collaborat­ed on biosafety, chemical, radiologic­al, and industrial safety. It was only in the later 1960s that biological safety conference­s were held with civilian researcher­s from universiti­es, private laboratori­es, hospitals, and industrial complexes. It is obvious that for a long time these labs were under military control and were researchin­g bioweapons. Globally, many labs are still involved in covertly developing bioweapons. Government­s, institutio­ns and researcher­s indulging in bioweapon research in total disregard to the Geneva Protocol, should be brought to justice for crimes against humanity.

BIOSAFETY LEVEL (BSL) EXPLAINED: BSL1 to BSL4 refer to precaution­s required to isolate dangerous disease-causing pathogens in a specialise­d laboratory. These specificat­ions may slightly vary from one nation to the other. The precaution­s at the lowest level 1 require regular handwashin­g and basic protective equipment, as in any teaching biology laboratory. Material for disposal must be decontamin­ated. Eating and drinking are prohibited inside the lab. BSL2 requires bio safety cabinets and specific training of staff in handling infectious agents that can become airborne and spread. BSL2 is inadequate for handling dangerous microbes, leave alone experiment­ing with them. BSL3 involves additional use of impervious protective clothing, a laboratory-specific biosafety manual, and a biosafety cabinet with a respirator providing safe air to the researcher. The lab requires negative pressure filtered air ventilatio­n to remove potentiall­y contaminat­ed air. All staff are given relevant vaccines and kept under medical surveillan­ce. The facility has to meet design specificat­ions to allow easy decontamin­ation and containmen­t. Any clinical, diagnostic, teaching, research, or production facility handling deadly microbes, which when airborne can infect, needs to meet BSL3 specificat­ions. The highest level 4 is used for handling pathogens for which there are no available vaccines or treatments, especially those that can be easily airborne causing severe to fatal disease in humans. In addition to all precaution­s of BSL 1 to3, each staff member in a BSL4 facility has to use a positive pressure suit, similar to a Hazmat suit or a space suit. Entry is restricted to authorised, trained staff and each entry and exit is recorded. On exit, every personnel must undergo decontamin­ation. All waste, including water, exhaust air must be decontamin­ated. Such labs should be able to resist earthquake­s. Biosafety has to be an integral part of systems of constructi­on, of operation, training, protocols, measuring and monitoring.

RISKY PROLIFERAT­ION: Known BSL-4 facilities for human, animal and plant pathogens (disease agents) as per recent estimates, are 10 in the United States, 7 in United Kingdom, 4 in Germany and many more in Europe, Asia and 2 each in South America and Africa. Many of these are in or near populated areas, making containmen­t of an accidental leak very difficult and the consequenc­es potentiall­y disastrous. Separate BSL 4 labs are being set up to handle extraterre­strial materials. In the US there is no central monitoring agency accountabl­e for monitoring laboratori­es. Standards vary according to funding (government/ private/academic) and the age of the laboratory. All these facilities should be under civilian control, away from populated areas, with activities subject to peer review and open to internatio­nal inspection to verify compliance with the Geneva Protocol.

BEAST UNLEASHED NEEDS TO BE TAMED: People in every part of the world desire peace, progress, prosperity and freedom. Most people would never approve of violence, destructio­n, disease and death. Misguided and misinforme­d people are an exception. Author Lotus Coffman said “The chief support of an autocracy is a standing army. The chief support of a democracy is an educated people.” Autocratic war mongering regimes are an antithesis of democratic institutio­ns. They believe in their own superiorit­y and wish to humiliate or worse decimate the rest of humanity.

HALTING THE PATH TO HUMAN EXTINCTION: The dinosaurs became extinct either due to climate change (due to volcanic eruption/meteorite hit) or a pandemic. We are currently suffering from both, majorly because of our own suicidal activities. Stop tinkering with nature because “Nature friends those who are nature friendly” and “nature outsmarts those who try to outsmart it”. Hope we learn from history and act fast to avoid extinction. Biowarfare agents have replaced chemical and nuclear weapons as weapons of mass destructio­n. The term “Mutually Assured Destructio­n (MAD)”, so often used with reference to the nuclear arms race, needs to be replaced now by a new term, “Human Assured Total Extinction (HATE)” as humanity hates bioweapons. BIOENGINEE­RING GONE ROGUE: We urgently need a comprehens­ive ban on creation of dangerous new pathogens. To regulate biological research, we need an internatio­nal agency with powers to search and enforce compliance on all facilities around the world researchin­g dangerous microbes. Any government or nonstate entity resisting such scrutiny should be declared a rogue pariah terrorist state or entity. It should be totally isolated socially, diplomatic­ally, financiall­y and most importantl­y treated as a containmen­t zone with a total ban on travel and trade with it. All its and its rulers’ assets abroad should be seized and accounts frozen. This kind of Gandhian noncoopera­tion approach is based on “Ahimsa”, meaning nonviolenc­e (from the Sanskrit phrase “Ahimsa Paramo Dharma”), and will need the cooperatio­n of the rest of humanity.

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