Study: Los­ing 10% of body weight key to rev­ers­ing di­a­betes

This fat mol­e­cule may help con­trol blood su­gar lev­els

The Times of India (New Delhi edition) - - Times Trends -

Lon­don: Peo­ple who can re­duce their weight by 10% or more within the first five years of di­ag­no­sis with type 2 di­a­betes have the great­est chance of go­ing into re­mis­sion, ac­cord­ing to a study which suggests that it is pos­si­ble to re­cover from the dis­ease with­out in­ten­sive life­style in­ter­ven­tions, or ex­treme calo­rie re­stric­tions.

Type 2 di­a­betes which af­fects more than 400 mil­lion peo­ple world­wide, in­creases the risk of heart dis­ease, stroke, blind­ness, and am­pu­ta­tions, the study, pub­lished in the jour­nal Di­a­betic Medicine, noted.

The re­searchers, in­clud­ing those from the Univer­sity of Cam­bridge, said that while type 2 di­a­betes can be man­aged through a com­bi­na­tion of pos­i­tive life­style changes and med­i­ca­tion, it was also pos­si­ble for the pa­tients’ high blood glu­cose lev­els to re­turn to nor­mal if they went through sig­nif­i­cant calo­rie re­stric­tion and weight loss.

Stud­ies have es­tab­lished that an in­ten­sive low-calo­rie diet con­sist­ing of 700 calories daily in­take — less than one cheese­burger — for a pe­riod of eight weeks was as­so­ci­ated with re­mis­sion in al­most nine out of ten peo­ple re­cently di­ag­nosed with the dis­ease, and in half the num­ber of peo­ple with long­stand­ing dis­ease, the re­searchers said. Re­searchers

have dis­cov­ered that a fat mol­e­cule 12-HEPE — pro­duced in the hu­man body in re­sponse to cold ex­ter­nal tem­per­a­tures — plays a role in re­duc­ing the blood su­gar lev­els, an ad­vance that may pave the way for new di­a­betes treat­ment meth­ods. When the re­searchers, in­clud­ing those from the Univer­sity of Camp­inas con­ducted lab­o­ra­tory tests with hu­man cells, they found that 12-HEPE in­creased glu­cose up­take by adi­pose cells. Ac­cord­ing to the re­searchers, this sug­gested that the lipid mol­e­cule played a role in adap­ta­tion to cold, and also in the “dras­tic re­duc­tion” of lipid lev­els in the blood­stream of obese in­di­vid­u­als — which is partly due to in­creased blood su­gar.

The re­searchers said that peo­ple who could re­duce their weight by 10%, or more, within the first five years af­ter di­ag­no­sis were more than twice as likely to go into re­mis­sion — com­pared to those who main­tained the same weight af­ter the pe­riod.

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