Test that spots MND signs could lead to crucial earlier treatment

Scientists have developed a ‘game-changing’ test that spots signs of motor neurone disease (MND) before symptoms of the illness appear in sufferers.

The tool, known as TDP-43 aptamer, is able to detect damaged cell proteins in brain tissue samples.

Researchers said these proteins are indicators, or biomarkers, of MND that can be spotted before cells begin to malfunction and symptoms start to appear.

They said that detecting the condition at its earliest stages opened the door for more effective treatments.

“Our findings have implications for early diagnostics and intervention prior to symptom onset in MND,” Dr Holly Spence, from the University of Aberdeen, said.

“With better ability to detect disease, we might be able to diagnose people with MND earlier, when therapeutic drugs might be much more effective.”

Charlie Bird, the former RTÉ journalist who died earlier this month, had been diagnosed with MND in 2021.

There is no cure for the condition, but treatments can help reduce its impact on a person’s daily life.

MND is caused by a build-up of certain proteins in the brain that clump together, causing the cells to gradually stop working.

Symptoms include impaired movement, thinking and breathing, which worsens over time.

The researchers said their test could pick up indicators of MND earlier and with more sensitivity than methods currently used.

Dr Jenna Gregory, from the university, said: “This tool ‘targets’ the disease protein and allows us to see where toxic clumps are building up in the body.

“It can do this for much lower amounts of disease proteins, and with greater accuracy than ever before.

“This could be a game-changer for MND research, diagnostics and treatment.”

The research was funded by Target ALS and is published in the journal Acta Neuropathologica.

Commenting on the research, Dr Brian Dickie, director of research at the Motor Neurone Disease Association, said: “It often takes a year from the first onset of symptoms to receiving a diagnosis of MND.

“This innovative research into the early cellular changes occurring in MND offers exciting potential for the development of new tests to help reduce diagnostic delay.

“As treatment does not begin until the disease is diagnosed, earlier intervention will hopefully also mean that treatments are more effective.”