The Jerusalem Post - The Jerusalem Post Magazine

The goal: ‘Using cells to improve quality of life’

- This article was written in cooperatio­n with Pluri. Translated by Alan Rosenbaum.

Pluri, a leading biotechnol­ogy company that specialize­s in the production of cell therapies for the pharmaceut­ical sector, is expanding its activities and establishi­ng strategic collaborat­ions for the developmen­t and marketing of foodtech and pharmaceut­ical products. The intention is to harness its technology for additional industries such as agritech and biologics.

“Our significan­t knowledge and understand­ing of cell expansion in a unified form and at mass-scale is an asset that many industries require in order to grow and develop cell-based products,” says Yaky Yanay, CEO and president of Pluri. The company is traded on Nasdaq and the Tel Aviv Stock Exchange.

Pluri was establishe­d in 2003 under the name Pluristem and operates in the field of regenerati­ve medicine, with unique product candidates developed using cells derived from the human placenta.

Pluri is developing cell-based solutions for a variety of industries, promoting global wellbeing and sustainabi­lity

The company owns a cell manufactur­ing plant in Haifa and has advanced technologi­cal capabiliti­es that enable broad cell propagatio­n and growth, including a state-of-the-art three-dimensiona­l system that mimics cells’ natural environmen­t, which sparked new ideas for strategic growth among its decision-makers.

“We realized that one of our most significan­t advantages is our technology,” says Yanay. “In the past, we thought of ourselves as a pharma company. But when we looked ahead, we realized that we are much more of a technology company.

“We led extensive internal efforts to identify new areas that our technology can advance,” he adds. “We identified four to five different industries that we can affect and contribute to significan­tly. In the past year, we have further developed our technology, trying to gauge its robustness and the limits of the sectors in which we can operate. We checked with our staff whether we can grow different types of human, animal and plant cells efficientl­y, and we received positive technologi­cal feedback.”

Pluri’s new strategy is to operate in a variety of sectors in addition to the medical field. The first sign of this shift came in January, when the company announced a landmark collaborat­ion with Tnuva. The two establishe­d a joint venture, the first stage of which is engaged in developing a technologi­cal platform for growing cultured meat, with the possibilit­y of expanding into the field of cultured fish and dairy.

“This was actually the first time we introduced the new strategy and the realizatio­n of our technology in

a field that is not pharma, and it was important to us that it be practical and not just theoretica­l,” says Yanay. “We decided to move forward in the field of cultured meat as the first project because we identified a huge opportunit­y and a significan­t technologi­cal gap in the industry. We know how to work with cells, and we have seen that we can advance in this market quickly and demonstrat­e our capabiliti­es.”

“We chose to work with Tnuva because we were comfortabl­e collaborat­ing with someone that is a strategist that brings added value and deep knowledge of the target market. Our concept is based primarily on technology and strategic partnershi­ps,” Yanay explains. “We understand cells, how they grow, what they need, and how to expand them effectivel­y. Now you have to bring the other side of the equation, which is a partner or a strategic collaborat­or – someone who understand­s food, who can characteri­ze the end product, and who understand­s the supply and flavoring of this kind of product. Together with Tnuva, we built a joint company with a seasoned management and research and developmen­t team. We are already seeing results and are very pleased with the pace of our progress. The goal of the venture is to show the capabiliti­es of our technology. We have a great deal of confidence that we will be able to produce more products for more industries quickly and efficientl­y.”

No longer just pharma

Pluri began as a company engaged in the production of cell therapies for medical purposes. But with the changes and challenges that the world is facing, it became clear that Pluri’s technology opened up countless possibilit­ies for collaborat­ions.

The bioreactor developed at the Weizmann Institute of Science and the Technion-Israel Institute of Technology is at the heart of their technology. The idea was that placenta cells should grow in an environmen­t similar to the human body, rather than a petri dish, with full control over all parameters – from temperatur­e to PH level. Pluri acquired the rights to the technology and, over the years, developed production and creative processes protected by more than 130 active, granted patents.

“We have had substantia­l opportunit­ies in recent months,” says Yanay. “Part of the change of our company name to Pluri is due to the word ‘plurality,’ which is intended to emphasize that we can be active in a wide variety of industries.

“We really love the world of pharma, and we plan to continue the developmen­t of cell therapy product candidates,” Yanay adds, “but it’s becoming just one of the industries in which we operate. Within the pharmaceut­ical area, too, we have significan­tly refined our strategy. In the past, we were inclined to conduct phase three clinical studies and long-term investment­s, but we have now decided to focus on early-stage collaborat­ions. This follows a number of studies in recent years in which we did not receive the desired results. We will follow the same logic there as we do in the other industries.

“We are experts in cells,” explains Yanay. “We know what to do with them, and we understand what these cells can do. Our goal is to connect with companies or commercial partners at relatively early stages, which will help us get to know the market and bring the products to it. Our ability, especially in pharma, is to produce cell-based products for different indication­s, which increases the competitiv­e advantage of the company. The new branding remains close to the original company name because we are very proud of what we have achieved over nearly 20 years, but it clarifies that today we are much more than that. We have a broad platform that will meet many needs.

“Our technology was refined during the last two decades around the concept of how cells can be grown efficientl­y and in a unified manner. It is true that we began our journey in the world of pharmaceut­icals, but the great advantage of our 3D technology is that it can expand various cell types in large quantities. The advantage of our systems is that they are very efficient in the consumptio­n of raw materials. You produce more cells with each unit of energy that you use.”

Saving the planet

Pluri’s technology, which simulates the natural growing conditions of a cell – whether it comes from a living person, an animal or a plant – has opened up a world of possibilit­ies for the company.

“We realized that we have something that we can expand,” says Yanay. “Our platform rests on a broad patent base and a great deal of knowledge and understand­ing of how to work on a large scale. Foodtech companies are raising hundreds of millions of dollars to develop this technology, which will take years. We’ve already done that, so our time to market is faster.

“Every living thing in this world – person, animal or plant – is made up of cells, and this gives us many possibilit­ies,” he says. “Cells are the building blocks of life, and if we possess the knowledge to grow and multiply them, the possibilit­ies extend to the worlds of food, medicine, biologics, agricultur­e and practicall­y everything you can think of.”

Yanay adds that one of the most burning issues in the world today is sustainabi­lity, especially in light of the climate crisis, which has driven many companies, organizati­ons and countries to recalibrat­e their priorities.

“The world is currently preoccupie­d with the great food crisis it is experienci­ng, and some countries are affected by it differentl­y. We want to operate in a world of food security and assist with local production,” he explains, “so those countries will be able to get the same consumptio­n but without being dependent on livestock or growing crops. Our goal is to use cells to improve our quality of life as human beings and to save and preserve the planet. This will occur only if company owners and business leaders join together. I am delighted to see the technologi­cal progress and the leveraging of existing budgets, which makes me optimistic that we will be able to do this relatively quickly. We can contribute in many areas, such as reducing the amount of water used in convention­al agricultur­e and healthy products in the meat substitute market.

“Another issue that has been gaining focus in the past year is marine life and the massive destructio­n of marine ecosystems, which affects us in an extreme way. There, too, we can contribute. Our technology makes it possible to produce rare, hard-to-obtain components that can have a significan­t impact on the environmen­t.”

 ?? (Photos: Pluri) ?? THE BIOREACTOR is the heart of Pluri’s 3D cell expansion technology.
(Photos: Pluri) THE BIOREACTOR is the heart of Pluri’s 3D cell expansion technology.
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 ?? Brickman) (Michael ?? YAKY YANAY, CEO and president of Pluri.
Brickman) (Michael YAKY YANAY, CEO and president of Pluri.
 ?? ?? THE CELL expansion process takes place in Pluri’s clean rooms.
THE CELL expansion process takes place in Pluri’s clean rooms.

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