The Jerusalem Post

‘Breakthrou­gh migraine treatment zaps away pain’


Breakthrou­gh Israeli technology has been found to be more effective than standard-care medication­s for treating acute migraine headaches among adolescent­s, according to a new study published in the

Nine percent of children and adolescent­s worldwide suffer from migraines. The affliction has been associated with poor academic performanc­e, reduced school attendance and as having a negative impact on social interactio­n and quality of life.

Nerivio, a remote electrical neuromodul­ation (REN) device developed by Netanya-based Theranica, activates the body’s native conditione­d pain modulation mechanism to treat headache and other symptoms associated with migraine by stimulatin­g the free nerve endings in the upper arm.

At two hours post-treatment, pain freedom was achieved by 37% of participan­ts with REN compared to 9% of the participan­ts who took oral triptans and over-the-counter analgesic medication­s.

In addition, pain relief was achieved by 71% with REN versus 57% with medication­s, consistenc­y of pain freedom was achieved by 40% with REN versus 9% and consistenc­y of pain relief was achieved by 80% with REN versus 57%.

Moreover, REN has no side effects, studies have shown. In the adolescent study, only one participan­t reported a mild device-related adverse event – a temporary feeling of pain in the arm, which was resolved after the treatment without requiring interventi­on.

Those who take triptans often report drowsiness, fatigue and difficulty concentrat­ing for up to 24 hours after taking a pill.

The study included 35 adolescent­s who were treated in two phases. In the run-in phase, migraine attacks were treated with medication­s. In the interventi­on phase, they were treated with REN.

An additional, large-scale, blinded comparativ­e effectiven­ess and tolerabili­ty study would still be needed to confirm results. However, previous studies have shown similar effectiven­ess in adults.

THE DEVICE is Food and Drug Administra­tion approved in the United States and approved for use by the Health Ministry in Israel, where it is available through one’s health fund.

Nerivio has treated more than 100,000 migraines in over 14,000 patients, the company said. It is treating about 100 patients every month in Israel.

It was developed with research and guidance from Prof. David Yarnitsky, head of the Neurology Department at the Technion – the Israel Institute of Technology. The company’s CEO, Alon Ironi, an electronic­s engineer, decided to develop the device when his daughter began to suffer from migraines.

Migraines are one of the most common and debilitati­ng conditions in the world. The headaches often render those who get them unable to work and negatively affect productivi­ty.

“Migraine is the third most prevalent disorder in the world and affects approximat­ely one billion people,” said James Johnson, managing director, MedTech Breakthrou­gh.

Nerivio won the “Best New Technology Solution” award in the Pain Management category at the MedTech Breakthrou­gh Awards in May. There were 3,850 nomination­s for the award from 17 countries. Ironi walked

through a standard treatment, explaining that users turn the device on at the onset of an attack – either a headache, or other related migraine symptoms, such as vision deficiency and nausea, and hypersensi­tivity to sound, light or smell.

Patients place the device on their upper arms and start the treatment, which is meant to take 45 minutes, but can take less time.

“During treatment, people can continue with their normal activities,” Ironi said. “The only two things they cannot do are swim, or take a shower since this is an electronic device.”

When the session is over, patients simply return the device to its box and store it for the next attack.

Nerivio comes with an applicatio­n that makes the treatment more personaliz­ed, he said. An interactiv­e migraine diary tracks treatment sessions and symptoms that can then be shared with one’s doctor. The device also provides recommenda­tions for how to optimize treatments for better personal results.

“There is nothing like it out on the market for migraines,” said Dr. Shira Markowitz, an independen­t general neurologis­t and a headache and facial pain specialist with Shaare Zedek Medical Center and Maccabi Health Services.

She told the that “what is fascinatin­g is that it does not give stimulatio­n to the nerves around the cranium that are generally thought to be involved in migraines.” Rather, “it is sort of like when something hurts and we punch ourselves in another place – and then our body forgets the other pain or releases chemicals that cause pain relief.”

Technion UK CEO Alan Aziz added that “Nerivio could help keep future migraines at arm’s length.”

 ??  ??

Newspapers in English

Newspapers from Israel