New strategy to attack brain cancer shrinks tumors in test
WASHINGTON (AP) — A new strategy to fight an extremely aggressive type of brain tumor showed promise in a pair of experiments with a handful of patients.
Scientists took patients’ own immune cells and turned them into “living drugs” able to recognize and attack glioblastoma. In the firststep tests, those cells shrank tumors at least temporarily, researchers reported Wednesday.
So-called CAR-T therapy already is used to fight blood-related cancers like leukemia but researchers have struggled to make it work for solid tumors . Now separate teams at Massachusetts General Hospital and the University of Pennsylvania are developing next-generation CAR-T versions designed to get past some of glioblastoma’s defenses.
“It’s very early days,” cautioned Penn’s Dr. Stephen Bagley, who led one of the studies. But “we’re optimistic that we’ve got something to build on here, a real foundation.”
Glioblastoma, the brain cancer that killed President Joe Biden’s son Beau Biden and longtime Arizona Sen. John McCain, is fast-growing and hard to treat. Patients usually live 12 to 18 months after diagnosis. Despite decades of research, there are few options when it returns after surgery and radiation.
The immune system’s T cells fight disease but cancer has ways to hide. With CAR-T therapy, doctors genetically modify a patient’s own T cells so they can better find specific cancer cells. Still, solid tumors like glioblastoma offer an additional hurdle — they contain mixtures of cancer cells with different mutations. Targeting just one type allows the rest to keep growing.
Mass General and Penn each developed two-pronged approaches and tried them in patients whose tumors returned after standard treatment.
At Mass General, Dr. Marcela Maus’ lab combined CAR-T with what are called T-cell engaging antibody molecules — molecules that can attract nearby, regular T cells to join in the cancer attack. The result, dubbed CAR-TEAM, targets versions of a protein called EGFR that’s found in most glioblastomas but not normal brain tissue.
Both teams infused the treatment through a catheter into the fluid that bathes the brain.
Mass General tested three patients with its CAR-TEAM and brain scans a day or two later showed their tumors rapidly began shrinking, the researchers reported in the New England Journal of Medicine.