Stress tied to lower bone density after menopause

Med side effects rare

NEW YORK, Aug 6, (RTRS): Older women who are under a lot of social strain may be more likely to develop brittle, fracture-prone bones after menopause than their counterparts with worry-free lives, a recent study suggests.

Researchers followed 11,020 postmenopausal women over six years, giving them periodic bone mineral density (BMD) tests and mood assessments. Participants rated their level of social strain, or negative interactions or relationships; their social support, or positive relationships; and social functioning, or limitations in social activity.

Each one-point increase in social strain scores was associated with 0.082% greater loss of BMD in the neck, 0.108% greater loss of BMD at the hip, and 0.069% greater loss of BMD in the lower spine, the study found.

“Fractures are a major societal burden affecting 1 in 2 older women, due to a variety of risk factors that lead to bone loss,” said Shawna Follis, lead author of the study and a researcher at the University of Arizona in Tucson.

“We found that high social stress is one risk factor that increases bone loss in aging women,” Follis said by email.

Reduced estrogen production during menopause and afterward can slow production of new bone tissues in women. Over time, this process leads to decreased BMD and increases the risk of osteoporosis.

Osteoporosis

Bones thinned by osteoporosis are brittle and more easily fractured.

Much of the previous research into connections between osteoporosis and mental health has focused on whether impairment due to bone thinning or fractures might contribute to mood disorders like depression or anxiety, the researchers note.

In the current study, published in Journal of Epidemiology & Community Health, high levels of social stress were associated with lower BMD even after researchers accounted for other factors that can impact bone health like age, education, chronic health problems, weight, smoking status, alcohol use, hormone therapy, age at menopause, physical activity, and fracture history.

Lower social functioning was tied to greater decreases in BMD in the neck and hip, the current study found. And low social support was associated with greater decreases in the neck.

The study doesn’t prove that social stressors directly impact bone mineral density, and researchers also didn’t look at the connection between various social stressors and falls or fractures. And it’s impossible to say from the study whether easing of social stress would have any effect on bone health.

Still, the results suggest that older women who do a better job of managing stress may have healthier bones and a lower fracture risk, said Dr JoAnn Pinkerton, director of midlife health at the University of Virginia Health System in Charlottesville, Virginia and executive director emeritus of the North American Menopause Society.

“For women who are anxious or have higher social stress levels, mindfulness, cognitive therapy, self-calming strategies, yoga, counseling, access to community building, or, if needed, medications might decrease the psychosocial stress levels,” Pinkerton, who wasn’t involved in the study, said by email.

When women do have osteoporosis, there are still things they can do to prevent bones from becoming more brittle, Pinkerton added.

“Calcium, vitamin D and strength training may prevent further bone loss,” Pinkerton said. “Although many women are fearful of the side effects associated with medications for treating osteoporosis, the side effects are actually rare while fractures may be life changing.”

Osteoporosis medicines such as Fosamax (alendronate sodium), Actonel (risedronate sodium), and Boniva (ibandronate sodium) work by slowing down how fast the body removes old bone, allowing time to regrow bone and make fractures less likely.

These medicines can cause nausea and abdominal pain, as well as rare but more serious side effects like cracks in the thighbone or damage to the jawbone. Alternative treatments include estrogen or two injected medicines, denosumab and teriparatide.

Preventing falls among elderly patients who’ve just left the hospital is an important part of keeping them safe, a large US study shows.

When elderly patients are discharged, one of the major reasons they end up back in the hospital is that they’ve suffered a fall, researchers found.

“Hospitals spend a lot of time thinking about fall risk while the patient is in the hospital, but there’s much less attention to the patient after discharge,” said principal investigator Geoffrey Hoffman of the University of Michigan School of Nursing. Fall prevention efforts need to continue as the patient moves from the hospital to home, or elsewhere, he said.

Hoffman and colleagues analyzed data on more than 8.3 million patients, age 65 and above, who were hospitalized in 2013 and 2014. About 14% of the patients were readmitted within 30 days of being discharged.

Readmitted

Among these patients, about 5% were readmitted due to injuries caused by falling, making it the third leading cause of readmissions after blood poisoning due to bacteria and heart failure.

The prevalence of falls after discharge suggests there is a gap in the quality of care provided before and after patients leave the hospital, Hoffman said.

“Promoting mobility in and outside the hospital is critical,” Hoffman told Reuters Health by phone.

Medicare, the government insurance program for older Americans, penalizes hospitals when patients fall. To minimize these penalties, hospitalized patients at high risk of falling may be discouraged from getting up and moving around without assistance. This enforced immobility could increase the risk of falls after discharge, the researchers noted.