Antibody shields monkeys from ‘HIV’ for months — study

PARIS: Just one shot of a lab-produced antibody protected macaques against a sort of monkey HIV for nearly six months, said a study Wednesday into a potential vaccine alternative.

Exposed to simian HIV (SHIV) once a week, non-treated monkeys contracted the virus after just three weeks on average, the researchers said, whereas the trial monkeys remained virus-free for up to 23 weeks.

In human populations at high risk of contracting the AIDS-causing virus, such protection, even temporary, “could have a profound impact on virus transmission,” the team of German and US-based researchers reported in the journal Nature.

They had examined ‘passive immunisation’ as an alternative to an HIV vaccine, which experts fear may still be years off.

A vaccine works by priming the body to respond with germ-fighting antibodies whenever a virus or bacteria invades. It is longlasting, sometimes for life.

‘Passive immunisation’ involves the transfer of antibodies generated by one person directly to another to provide protection, which is shorter-lived.

Antibody shots were used to protect travellers against Hepatitis A until a vaccine became available in the 1990s, and some hope the technique could stave off millions of HIV infections until a vaccine comes to the market.

Transferred antibodies had previously been shown to protect animals against HIV-like viruses for a day or two, but never as long as in this study.

Since the outbreak started in the early 1980s, about 71 million people have been infected by HIV, and some 34 million have died, according to UN estimates.

There is no cure, and the only way of dealing with HIV is lifelong reliance on antiretroviral drugs, invented in the 1990s, to stop the virus from replicating.

The treatment carries side effects and is costly.

The quest for a vaccine has been long and frustrating, in spite of hundreds of millions of dollars in funding.— AFP