US Novavax delays Covid vaccine authorisation request
US biotech firm Novavax on Monday said it had delayed plans to seek authorisation for its Covid vaccine candidate, a setback for developing countries hoping the injection would soon be available.
The company now hopes to file for authorisation in the US and Europe in the third quarter of 2021, it said in a statement, sending shares tumbling 12 percent.
Novavax’s vaccine is key to the Covax programme, which was set up to try to ensure poor countries have equitable access to vaccines to combat the coronavirus pandemic.
Its NVX-CoV2373 vaccine candidate demonstrated 100 per cent protection against severe disease in a Phase 3 clinical trial in Britain, with 89.7 per cent efficacy against any form of the disease.
It uses a piece of the SARSCoV-2 virus called the spike protein, which the company mass-produces inside insect cells, and can be stored at regular refrigeration temperatures.
Novavax also said Monday it had had positive results from preclinical studies of a shot combining its influenza and Covid vaccine candidates.
The company said a study, which will now undergo peer review, showed that the shot produced strong levels of antibodies against both diseases in ferrets and hamsters.
“Despite low rates during the Covid-19 pandemic, influenza remains a significant risk to global public health and the need for versatile, more effective vaccines is as important as ever, including against the flu,” said Gregory Glenn, the company’s president of R&D.
The new vaccine combines NanoFlu and NVX-CoV2373.
Hamsters that were vaccinated and then deliberately infected with the coronavirus retained their body weight compared to those that received a placebo.
Lung samples taken from the immunised animals after they were put down showed they were Covid-free. —