Quest for AIDS cure hits setback

Scientists voice concern over ‘evidence’ linking HIV drug to birth defects

AMSTERDAM: Scientists reported setbacks in the quest for an AIDS cure, and highlighted concerns about inconclusive evidence linking a promising new HIV drug to birth defects.

According to research presented at the 22nd International AIDS Conference in Amsterdam, four cases of “neural tube” defects were recorded among the pregnancies of 426 HIV-positive women in Botswana who took the drug dolutegravir before conception.

Neural tube defects cause severe brain and spinal deformities in the first weeks after conception, and often lead to stillbirth.

The cases amount to a ratio of nearly one defect per 100 pregnancies, compared to the rate in the general population of about one per 1,000, researcher Rebecca Zash of the Harvard TH Chan School of Public Health explained.

The defects were observed between August 2014 and May this year.

There have been no new reports among 170 dolutegravir pregnancies monitored since, but Zash said, “I don’t think we can take much reassurance from that”.

Four birth defects in 596 pregnancies was “still seven times higher than other groups, and statistically significant”, she added.

Dolutegravir is a relatively new HIVsuppressor with fewer side-effects, and is thought less likely to spark drug resistance in patients.

Countries targeted by the US PEPFAR AIDS relief fund were on the cusp of rolling it out as the leading antiretroviral therapy (ART), International AIDS Society president LindaGail Bekker said.

Botswana was the first country to introduce dolutegravir as a first-line antiretroviral drug for all who need it, including women of child-bearing age.

“This puts a very definite bump in the road,” Bekker said, adding that conference

It’s tough, but I think we just have to wait for more information.

Rebecca Zash

organisers “scurried” to organise last-minute sessions to discuss the consequences of the Botswana results.

Pending clarification, global health agencies have advised HIV-positive women planning a family to use other antiretrovirals instead.

“I wish so badly that this data signal would go away with further research,” Zash said.

In the meantime, “it’s tough, but I think we just have to wait for more information”. On the cure front, there was bad news too. A trial to test a new strategy to “kick” the AIDS-causing HIV virus out of its hiding place in human cells, then “kill” it, yielded a disappointing outcome.

Researchers tested the effects of several medicines on top of standard ART in a trial with 60 HIV-positive men.

Volunteers received two vaccines meant to coach the body’s immune system to recognise HIV, and another drug to “wake up” the reservoir cells hiding the virus, allowing it to be attacked by the body’s own defences.

But trial participants who received these drugs had no different outcome to those on standard ART, said Sarah Fidler, a professor of HIV medicine at Imperial College London who took part in the research.

“Of course the overall effect wasn’t what we would hope for, but it was definitive,” she told journalists in the Dutch capital.

“All results move the knowledge forward even if they’re somewhat disappointing.” — AFP