Flu shot less effective for obese adults

ALTHOUGH an annual influenza, or flu shot, is a common precaution and one of the best ways for many to protect against being struck down with illness, a new study suggests that the vaccine may not be as effective in obese adults.

This new study, carried out by a team from the University of North Carolina at Chapel Hill, the US, set out to look at the effect of obesity on the vaccine, which is a growing global problem already linked with a variety of health conditions.

It is also already known to increase a person’s risk of dying from influenza.

The team of researchers looked at 1,022 adults who were a healthy weight, overweight or obese, and who all received the seasonal trivalent inactivated influenza vaccine (IIV3) during the 2013-2014 and 2014-2015 flu seasons.

The team used lab tests and reported symptoms to confirm whether participants went on to develop flu or experience influenzalike illness, and to which degree their bodies produced influenza-fighting antibodies following vaccination.

Although they all received the vaccine, a small percentage of participants still became ill.

However, when looking at the obese group, the team found that these participants were twice as likely to develop influenza or flu-like illnesses as those in the healthy weight group, with 9.8% of obese participants showing confirmed influenza or influenza-like illnesses, compared with 5.1% of those of healthy weight.

The study’s co-author Melinda Beck suggested that the flu shot may not be as effective in obese people because their T cells, which support the protection and recovery from flu, do not function properly.

The team have also found previously that obese people have impaired T cell responses to influenza vaccine.

After using a blood serum tests to look at the participants’ levels of antibodies, which build up in the body to fight off an infection such as influenza, the team found no differences in the levels of antibodies between vaccinated participants with flu symptoms and those without, or between obese participants and healthy weight participants.

However, lead author Scott Neidich pointed out that the impaired T cell functioning may still make obese adults more at risk of flu despite a good production of antibodies.

He suggested that “alternative approaches may be needed to protect obese adults from both seasonal and pandemic influenza virus infections”. – AFP-Relaxnews