The New Zealand Herald

After Brisbane shock, a dose of good news

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The decision to lock down Greater Brisbane for three days this week has been another reality jolt for those dreaming of unfettered travel across the Tasman. Queensland recorded 10 new cases of Covid-19 on Monday, bringing the community cluster in Brisbane to seven cases.

Under pressure for some months to open up travel between Australia and New Zealand, our Prime Minister has rightly pointed out the Brisbane outbreak is another reminder of the need for caution in any change to border controls.

However, the release of a report from the Centres for Disease Control and Prevention this week is a coincident­al counter to that, and further cause for optimism.

New York epidemiolo­gist Celine Gounder said the results were real-world evidence that the Pfizer and Moderna mRNA vaccines prevent infection, not The “interim estimates of vaccine effectiven­ess” presented new data from tests carried out on US frontline workers who had received the PfizerBioN­Tech and Moderna vaccines at eight locations.

The report was compiled from results from prospectiv­e cohorts of 3950 healthcare personnel, first responders, and other essential and frontline workers who completed weekly Covid-19 testing for 13 consecutiv­e weeks. Under these “real-world conditions”, the messenger RNA vaccine effectiven­ess of full immunisati­on (14 days after the second dose) was found to be 90 per cent against Covid-19 infections regardless of symptom status; and 80 per cent 14 days after the first dose, but before the second dose.

The finding is a further advance on analysis from Phase III trial results and two other recent estimates of vaccine effectiven­ess for partial immunisati­on with the Pfizer-BioNTech vaccine..

A UK trial had put vaccine effectiven­ess at 60 per cent by 14 days after the first dose.

The US authors of the latest CDC report said their findings conclusive­ly show authorised mRNA Covid-19 vaccines are effective for preventing Covid-19 infection in actual vaccinatio­n rollouts.

“These interim vaccine effectiven­ess findings for both Pfizer-BioNTech’s and Moderna’s mRNA vaccines in real-world conditions complement and expand upon the vaccine effectiven­ess estimates from other recent studies and demonstrat­e that current vaccinatio­n efforts are resulting in substantia­l preventive benefits among working-age adults. Covid-19 vaccinatio­n is recommende­d for all eligible persons,” they concluded.

The news that a single dose of New Zealand’s preferred Pfizer vaccine is so effective could be grist to considerat­ions of rolling out first doses sooner and wider, rather than the one-two shot for each person that has been carried out so far.

Philadelph­ia Professor of Vaccinatio­n Dr Paul Offit has warned against dropping the second shot entirely however, as he said it provided “durable” protection.

Once again, science is providing an uplifting flipside to the disappoint­ments as this pandemic runs its course.

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