The New Zealand Herald

NZ start-up to make lab-grown meat easy

- Chris Keall

We hope that cultivated meat will decrease our global reliance on intensive agricultur­e, such as the beef feedlot systems used throughout much of the world. Olivia Ogilvie

A Kiwi start-up in the “cultivated meat” sector — or what many traditiona­l farmers call “vat-grown meat” — has broken cover.

Opo Bio is officially out of stealth mode this week.

Co-founder Olivia Ogilvie explains that, simply because the field is so new, cultivated meat has mostly involved vertically integrated companies — or outfits that cover all of the necessary steps themselves — from sourcing cell lines to the “media” that nourishes them (what Ogilvie calls “Powerade for cells”) to the “growth factors” (signals that tell the cells to divide) and the edible (it can be made of gelatin) “scaffoldin­g” that the meat grows on, in lieu of preexistin­g muscle.

But now that the sector is getting closer to commercial­isation, companies dedicated to various parts of the process are starting to emerge.

In Opo Bio’s case, it’s focusing primarily on cell lines from livestock, with a sideline in media. At the moment, the start-up is mostly working with cow and pig cells, but also doing some work with sheep.

The process starts with tissue samples taken from livestock. “We take a sample of cells from muscle, fat and connective tissue,” Ogilvie explains.

“That’s what meat is made up of; those three components.

“We isolate those cells and we do some science on them to isolate our cells that grow faster and need less food — just like some animals grow faster and need less food.”

How quickly animal meat grows, and its flavour, depends on the distributi­on of fat, muscle and connective tissue cells. The same holds true for cultivated meat — only with scope for tweaking the mix.

“Basically what we do is we design the best ‘seeds’ to grow meat and those seeds are cells,” Ogilvie says.

“Once you develop the best cell line, you’d sell it to the producer.

“We hope that, in the same way companies breed bull semen, each year we’ll have another version that’s more competitiv­e; that gives higher yields and different genetic characteri­stics to the year before.” Ogilvie’s pitch is that the cells her firm draws from cows, sheep and chicken will be processed to grow faster and more efficientl­y. Currently, her outfit has only one direct competitor, Scotland’s Roslin — whom you won’t have heard of, but some of its previous output you will be familiar with: Dolly, the first cloned sheep.

Opo — founded in February — was spun out of research by Ogilvie and co-founders Dr Laura Domigan and Dr Vaughan Feisst at Auckland and Canterbury universiti­es; it’s based around intellectu­al property developed by Domigan. The former’s commercial­isation arm, Uniservice­s, is one of its backers.

In July, it raised $1.5 million in a seed round supported by venture capital firm Matū , Booster (a KiwiSaver operator with a line in ethical investing), Auckland University’s Inventors’ Fund, and angel investors.

The start-up is releasing its first product — cell lines for researcher­s — this week. It aims to provide cells for commercial­ly cultivated meat-makers within a year. All going well, a “much larger” Series A capital raise is planned for next year.

On Opo’s radar is everyone from specialise­d cultivated meat firms like Vow in Australia and Upside Foods in the US to traditiona­l meat giants, like Tyson Foods in the US, that are now weighing their options in the emerging sector.

That doesn’t mean you’ll be tucking into a vat-grown chicken for your Christmas roast next year. Ogilvie’s ballpark estimate is that it will be around seven years before all the technology, regulatory and manufactur­ing scale elements fall into place for commercial­ly-viable cultivated meat.

A McKinsey & Co report estimated the cultivated meat market could reach US$30 billion ($48.85b) by 2030. “This isn’t like a replacemen­t for animal agricultur­e,” Ogilvie says.

“We see it as an ‘and’ not an ‘or’. We see this as something that New Zealand can do alongside all the other farming systems that we already have. It’s just a different type of farming.

Beef + Lamb NZ general manager, market developmen­t Nick Beeby says his organisati­on did a lot of research three years ago as plant-based “meat” emerged — and he says a lot of the findings and strategy will hold true with cultivated meat (or “petri-dish” or “vat-grown” as he tends to refer to it. Ogilvie prefers to compare the cultivatio­n process to a brewery).

His organisati­on identified a segment of what it calls “conscious foodies” around the world, who are wary of meat from grain-fed, feed-lot farming and the chemicals used, in some cases, with plant-based alternativ­es.

He sees that consumer skepticism carrying over to cultivated meat.

“Our target consumer is rejecting the idea of an over-processed product. So we see a clear line of sight for our natural farming systems,” he says.

Beef + Lamb has a “Taste Pure Nature” campaign running in the US and China. The answer to the cultivated meat threat will be more of the same messaging, and to amplify what his organisati­on sees as its advantages.

“There’s still a remarkable opportunit­y to supply these consumers with a completely natural, grass-fed free range product,” Beeby says.

“They have a strong belief that a natural and well-farmed product will be better for their own personal health and wellbeing.” Beeby points out that one of the biggest players in alternativ­e proteins, Beyond Meat, has seen its shares fall more than 80 per cent over the past 12 months.

(Earlier this month, Beyond said it would lay off 200 people, or around 19 per cent of its staff, after wider than expected losses on revenue that fell 22 per cent to $82.5m.) He says after a lot of early hype, plant-based meat alternativ­es have reached what he sees as a saturation level before many expected. He says cost and “mouth feel” are factors.

“I think they [cultivated meat makers] will face many of the same challenges,” he says.

Ogilvie is in fact, broadly on the same page. The target is battery-style farming, and all of the issues around animal welfare, environmen­tal harm, and people developing resistance to the antibiotic­s it uses so heavily.

“We hope that cultivated meat will decrease our global reliance on intensive agricultur­e, such as the beef feedlot systems used throughout much of the world,” she says.

She sees local farmers as partners. “One of the things that we are doing is that we are giving money back to the farms that supply us with tissue.”

 ?? Photo / New York Times ?? A chicken dish featuring lab-grown meat from Upside Foods in West Berkeley, California.
Photo / New York Times A chicken dish featuring lab-grown meat from Upside Foods in West Berkeley, California.
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