Stress cure on horizon

Soldiers could be cured of posttraumatic stress disorder (PTSD) by erasing memories of disturbing events, scientists believe.

Researchers at the University of Toronto have discovered that individual memories are encoded in just a few cells of the brain, and hope they will be able to switch them off using drugs.

Figures from the Ministry of Defence show that about 400 soldiers a year report symptoms of PTSD and, in the last five years, the charity Combat Stress has received nearly 10,000 referrals largely linked to the wars.

Many more suffer similar trauma – with symptoms including flashbacks, insomnia and paranoia – from events such as child abuse, road accidents and crime.

Researchers hope they will be able to erase memories of traumatic events after turning off specific memories in mice.

‘‘Although there are millions of neurons in the brain, only a few of them are necessary to form a fear or threat memory,’’ said Dr Sheena Josselyn, associate professor in the Department of Physiology.

’’Our findings suggest that one day it could be possible to treat people with PTSD by erasing these traumatic memories. Our goal would be to find a pharmacological way to inactivate just these neurons, like a heat-seeking missile-like drug.’’

Memories are stored in cell networks called ‘‘engrams’’ and scientists discovered they could turn off memories by surgically removing engrams in mice.

The process is similar to that portrayed in the film Eternal Sunshine of the Spotless Mind, in which characters have memories of bad relationships removed at a clinic. In real life, Josselyn said memories would only be removed when they interfered with mental health.

She added: ‘‘We all learn from our mistakes. If we erase the memory of our mistakes, what is to keep us from repeating them? Our studies provide a proof-ofprinciple. However, our society needs to develop ethical policies around the potential use of this.’’

British experts also expressed concern. Professor Sir Simon Wessely, president of the Royal College of Psychiatrists, said: ‘‘This is an interesting advance but we need to be cautious.’’ – Telegraph Group