Cape Times

ONGOING CHALLENGES OF AIDS

- THERESA ROSSOUW Rossouw is a professor in the Department of Immunology at the University of Pretoria

WORLD Aids Day is observed annually to bring attention to the pandemic and recognise global efforts to prevent new infections. South Africa has made significan­t progress in the management of HIV – new infections are down by 36% since 2010 – but there is still much to be done.

Along with addressing socioecono­mic factors, gender-based violence and the low status of women, there must also be continued focus on prevention strategies, HIV testing among key population­s, and the long-term treatment of the millions of infected people in the country.

The country has the largest HIV burden in the world – 20% of people living with the virus and 14% of those newly infected live in South Africa, despite it being home to only 0.76% of the world’s population.

In 2018, one out of every five adults between the ages of 15 and 49, and one out of every eight people overall were living with HIV. SA also has the largest number of people becoming newly infected annually (about 240 000 in 2018).

The largest proportion of new infections occurs among women. Adolescent girls and young women between 15 and 24 years of age are particular­ly at risk – this group is four times more likely to be infected than men of similar age and accounted for 37% of all sexually acquired HIV cases in South Africa in 2016.

The reasons for the high infection rate among women speak to the role and perception of women in society, the commodific­ation of sex, stigma, poverty and gender-based violence.

The UN developed the 90:90:90 treatment targets to focus the intention of ending the HIV epidemic as a public health threat by 2030. By 2020, 90% of HIV-infected people should know their status; 90% of those with a known status should be on ART; and 90% of those on treatment should be virologica­lly suppressed.

Many countries, including Botswana, Eswatini and Namibia, have achieved this target and the goals will be increased to 95:95:95 in 2030. South Africa has performed very well in achieving the first target and, currently, an estimated 90% of infected people are aware of their status, up from 66.2% in 2014.

But the second target has been our Achilles heel, with only 68% of those who know they are infected currently accessing ART. This is especially true of men, who are more likely to start ART at a later stage of infection and so have almost double the mortality rate than women. Once on treatment, people tend to do well, with a virologica­l success rate of 87%. This number could, however, be an overestima­tion as many studies have reported high treatment failure and default rates. At best, it appears that only 62% of people living with HIV are currently on ART, while only 54% are virologica­lly suppressed.

Not only is the South African treatment programme the largest in the world (with about 4.8 million people on ART), but it is largely funded domestical­ly, with only 13% of HIV funding coming from external sources. With the introducti­on of a cheaper and more effective first-line regimen containing dolutegrav­ir, South Africa envisages reducing the cost of its billion-dollar treatment programme.

Together with the underlying imperative to urgently address poverty, gender-based violence and the low status of women in society, attention should be paid to prevention, consistent condom use and targeted HIV testing, with special considerat­ion of the needs of key population­s: adolescent girls and young women, men and the elderly. Once tested, linkage to, and retention in care, should be actively managed and monitored. Finally, innovative ways of ensuring the long-term management of the millions of people in need of treatment, possibly incorporat­ing differenti­ated models of care, should be explored. | voices360.com

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