The Star Early Edition

SA has changed tack on mitigating impact

- SHABIR A. MADHI, FAREED ABDULLAH AND JONNY MYERS Madhi is the Dean of the Faculty of Health Sciences and Professor of Vaccinolog­y at the University of the Witwatersr­and; Abdullah is the director: Office of Aids and TB Research, South African Medical Rese

IN THE final days of 2021 the government eased its Covid regulation­s. On December 30, the government scrapped a curfew that had been in place since March 2020.

It also initially announced an easing around quarantine­s and contact tracing but subsequent­ly reversed these plans. Neverthele­ss, its approach sets a new trend in how countries are choosing to manage the pandemic. Shabir Madhi and colleagues reflect here on the boldness and the risks.

What are the main elements of its new approach?

The government has decided to take a more pragmatic approach while keeping an eye on severe Covid cases and whether or not health systems are imminently under threat.

This reflects acceptance that government­s will increasing­ly be looking for ways to live with the virus cognisant of the detrimenta­l indirect effects that restrictio­ns have been having on the economy, livelihood­s and other aspects of society. This is particular­ly pertinent in resource constraine­d countries such as South Africa.

The latest announceme­nts mark a significan­t departure in the way forward. They mark a pragmatic approach that balances the potential direct and indirect detrimenta­l effects of Covid.

Our hope is that the government continues to pursue this approach and doesn’t blindly follow policies that are not feasible in the local context, and ultimately yield nominal benefit.

The new, more nuanced approach is in stark contrast to reflexivel­y imposing higher levels of restrictio­ns as case rates increased.

This suggests that the government has taken note of commentary that has provided suggestion­s to focus on whether the health facilities are imminently under threat, rather than simply going to higher levels of lockdowns.

The main element of the new approach arises from a high level of population immunity. A sero-survey conducted in the country’s economic hub, Gauteng, just prior to the onset of the Omicron wave indicated that 72% of people had been infected over the course of the first three waves. Sero-positivity was 79% and 93% in Covid-19 unvaccinat­ed and vaccinated people older than 50 years, a group that had previously made up a high percentage of hospitalis­ations and deaths.

The sero-survey data show that immunity against severe Covid in the country has largely evolved through natural infection over the course of the first three waves and prior to the advent of vaccinatio­n. This has, however, come at the massive cost of 268 813 deaths based on excess mortality attributab­le to Covid-19.

Is it clear what the goals are?

The goal has to be minimising hospitalis­ation and death. It is unnecessar­y to be stressing out the economy, other health services and livelihood­s in South Africa.

The death rate with Omicron wave in South Africa is on track to be approximat­ely one-tenth compared with the Delta wave. This means it possibly on a par with deaths caused by seasonal influenza pre-Covid – 10 000-11000 per annum.

This death rate also needs to be considered relative to other preventabl­e deaths. TB is an example, which is estimated to have caused 58 000 deaths in South Africa in 2019.

It’s impossible to say what the characteri­stics of future variants would be over time. But the experience with the Omicron wave in South Africa provides some comfort that immunity against severe disease and death will continue tracking downward, particular­ity if vaccine coverage can be increased to 90%, particular­ly in the 50-year-old plus age group. The high force of infection that has likely transpired with Omicron will also further contribute to enhancing protection against severe Covid-19 in the immediate future.

What are the risks?

The major risk is the unpredicta­bility of new variants that evade all aspects of past infection and vaccine induced immunity. But this is likely to be the result of the evolution of the virus rather than any changes in policy.

Another risk is failure to change the pandemic mindset and failure to appreciate that with Omicron the epidemic phase of Covid-19 is coming to an end. The country and all its institutio­ns and people need to prepare to get back to a previous life – most notably the health services.

The South African government appears to have come to appreciate that the past practices have had limited success in preventing infections, and fully appreciate­s the detrimenta­l effects that restrictio­ns have had on the economy and society. In addition, it has run out of road to continue with what has unfortunat­ely not yielded much benefit. Despite all the severe lockdowns, South Africa still ranks high with a Covid death rate of 481 per 100 000.

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