Daily Mirror (Sri Lanka)

HUMAN TRIALS OF CORONAVIRU­S ‘VACCINE TABLET’ ABOUT TO COMMENCE

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Millions of doses of a new Covid19 vaccine could be in production by the end of the year, according to a San Franciscob­ased scientist who has been praised by Dr. Anthony Fauci for his work in the past.

Immunologi­st

Dr. Sean Tucker is currently trialing several different vaccine candidates at his California lab – some of which will enter human trials at the start of July, and all of which are delivered by tablet rather than injection.

Speaking exclusivel­y to Dailymail.com, Tucker said: ‘My hope is that us and others will be able to have very large vats of [vaccine] material, millions and millions of doses by the end of the year, early next year.

‘I mean, to me that doesn’t seem unreasonab­le given the amount of money the US Government and others have provided.

‘We hope that a vaccine solution will allow things to open up and for people to be going out and about again.’

ucker, 52, is the chief scientific officer at Vaxart – a publicly listed biotech company that specialize­s in the developmen­t of oral recombinan­t vaccines.

Along with his eightstron­g team, he has been working seven days a week since January in a bid to come up with a viable vaccinatio­n for Covid-19.

He currently has several contenders, all of which are being fasttracke­d through trials.

The vaccines are made from a dead adenovirus – one of the causes of common colds - into which Tucker’s team have inserted some of the 30 genes that make up Covid-19’s DNA.

Adenovirus­es are extremely common and behind approximat­ely 10 percent of childhood illnesses and almost every child has had at least one illness caused by adenovirus­es by the time they reach 10.

Tucker explained: ‘We essentiall­y build in DNA that encodes proteins of Covid-19. If you put it in the intestine in the right context, you get a really strong immune response to those proteins.

‘Because we’re delivering it to a wet surface – the mucosa of the intestine – you get a great immune response throughout the blood but you also get antibodies and T cells at sites of the infection in the lungs.

‘That’s the way our vaccine works – it’s designed to mount an immune response on wet surfaces such as the respirator­y tract, which Covid-19 infects.’

Tucker said: ‘My hope is that us and others will be able to have very large vats of [vaccine] material, millions and millions of doses by the end of the year, early next year

 ??  ?? Unlike most vaccines, which are made to be injected, Tucker’s drug will be delivered in tablet form which, he says, is more quickly manufactur­ed and gets around the current global shortage of vials and syringes caused by the pandemic (DM)
Unlike most vaccines, which are made to be injected, Tucker’s drug will be delivered in tablet form which, he says, is more quickly manufactur­ed and gets around the current global shortage of vials and syringes caused by the pandemic (DM)

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