Gene-editing research by US-French duo wins Nobel Prize in Chemistry
EMMANUELLE Charpentier of France and Jennifer Doudna of the United States yesterday won the Nobel Prize in Chemistry for developing the gene-editing technique known as the CRISPR-Cas9 DNA snipping “scissors”.
“Using these, researchers can change the DNA of animals, plants and microorganisms with extremely high precision,” the Nobel jury said. “This technology has had a revolutionary impact on the life sciences, is contributing to new cancer therapies and may make the dream of curing inherited diseases come true.”
Charpentier, 51, and Doudna, 56, are just the sixth and seventh women to receive the Nobel Prize in Chemistry.
While researching a common harmful bacteria, Charpentier discovered a previously unknown molecule – part of the bacteria’s ancient immune system that disarms viruses by snipping off parts of their DNA. After publishing her research in 2011, Charpentier worked with Doudna to recreate the bacteria’s genetic scissors, simplifying the tool so it was easier to use and apply to other genetic material. They then reprogrammed the scissors to cut any DNA molecule at a predetermined site – paving the way for scientists to rewrite the code of life where the DNA is snipped.
The CRISPR/Cas9 tool has already contributed to significant gains in crop resilience, altering their genetic code to better withstand drought and pests. The technology has also led to innovative cancer treatments, and many experts hope it could one day make inherited diseases curable through gene manipulation.
The first time a woman was honored with the chemistry prize was in 1911 when Marie Curie, who also took the physics prize in 1903, won for discovering the elements radium and polonium. AGENCIES