Khaleej Times

Mosquitoes engineered to fight Zika virus and other diseases

- AFP

piracicaba — Scientists in Brazil are preparing to release millions of factory-bred mosquitoes in an attempt to wipe out their distant cousins that carry tropical diseases. The insects’ method: have sex and then die.

British firm Oxitec says its geneticall­y modified mosquitoes will swarm in among ordinary species such as Aedes aegypti, the insect that carries feared diseases such as Zika, dengue, yellow fever and chikunguny­a.

They will mate with the females of the ordinary mosquitoes, spawning babies with a geneticall­y inbuilt flaw that causes them to die quickly.

With their work done, the modified father mosquitoes will then give up the ghost themselves — as they are geneticall­y programmed to do.

Oxitec says its factory in the town of Piracicaba, northwest of Sao Paulo, can produce 60 million mutant mosquitoes a week.

Piracicaba is the world’s “first and biggest factory” of geneticall­y modified mosquitos, said Oxitec president Hadyn Parry.

“This is the only place where we have a factory like this. We can use this as a hub for Brazil,” said Parry, who traveled to Piracicaba for the plant opening. Currently their only Brazilian customer is the city of Piracicaba, “but we are having conversati­ons with several municipali­ties and states,” Parry said.

According to the firm, five field tests that they conducted between 2011 and 2014 — in Panama and the Cayman Islands, as well as the northeaste­rn Brazilian state of Bahia — showed the population of wild Aedes aegypti insects dropped by 90 percent after the mutant mosquitoes were released.

Oxitec does not yet have a sales permit from Brazil’s Anvisa health authoritie­s, and there are no epidemiolo­gical studies showing whether mosquito-carried diseases drop after the factory-bred insects are released.

Parry is not concerned. “We are still waiting for Anvisa approval — we have no date for it, but we expect it for 2017,” he said.

And none of this has stopped the mayor of Piracicaba from signing a four-year, $1.1 million deal with Oxitec.

In its first wave, the company will release 10 million factory-bred mosquitos each week into this city of 360,000 people.

The need for insect control is pressing, as the summer in the southern hemisphere approaches and the mosquito population — and cases of the diseases that they carry — is likely to boom. As of July nearly 1.4 million cases of dengue were recorded in Brazil, following the record 1.6 million cases in 2015, according to health ministry figures. In the same period 174,000 cases of Zika were reported.

The Zika virus outbreak began in late 2015 in Brazil and has since spread across the Americas.

Zika is particular­ly dangerous to pregnant women because it can cause birth defects such as microcepha­ly, in which babies are born with unusually small heads and brain deformitie­s. Zika infection has also been linked to a nerve and immune disorder called GuillainBa­rre syndrome.

Scientists keep the spacious rooms at the Piracicaba factory at temperatur­e and humidity levels ideal for mosquito breeding.

While female mosquitoes are kept for breeding, male mosquitoes of the OX513A breed — especially developed by Oxitec in 2002 — are released to mate with females in the wild, produce shortlived offspring, then die. —

 ?? AFP ?? A View of larvae of mosquito Aedes aegypti infected with the Wolbachia bacteria in Piracicaba, Sao Paulo, Brazil. —
AFP A View of larvae of mosquito Aedes aegypti infected with the Wolbachia bacteria in Piracicaba, Sao Paulo, Brazil. —

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