BBC History Magazine

Living forever

- Patricia Fara, emeritus fellow in the history and philosophy of science at Clare College, University of Cambridge

Elixir: A Story of Perfume, Science and the Search for the Secret of Life Basic Books, 320 pages, £20

The quest for rejuvenati­on has a tortuous history. Two thousand years ago, Maria the Jewess introduced distillati­on to produce an alchemical elixir of life, while WB Yeats later boasted that a vasectomy granted him a youthful surge of creativity. Napoleon swore by the regenerati­ve virtues of perfume, diluted as a drink or to bathe in, and got through around 60 bottles a month.

Elixir: A Story of Perfume, Science and the Search for the Secret of Life is a detailed yet absorbing adventure story about the research, rivalries and rituals characteri­sing 19th-century French chemistry. Deploying superb detection skills, academic Theresa Levitt has rescued from obscurity two friends, Edouard Laugier and Auguste Laurent, who searched for chemical order in living material – that is, the essence of life itself. Operating on the fringes of science, they worked secretly at night in a dilapidate­d laboratory at a Parisian perfume shop run by the Laugier family.

The back-room collaborat­ors staggered from one depressing situation to another: on his 30th birthday, Laurent wrote despairing­ly: “I have wasted my life.” He had originally studied mining but, after successful­ly producing naphthalen­e, decided to investigat­e further. His insistence that organic substances have a crystallin­e structure proved controvers­ial. Perseverin­g, Laurent eventually persuaded scientist Louis Pasteur that his unusual findings were significan­t – and they led to Pasteur’s landmark demonstrat­ion that molecules can be right or left-handed. To his amazement, Pasteur discovered that as a result of these mirror-image molecules, substances created artificial­ly behave differentl­y from natural ones with the same chemical formula.

In 1953, Francis Crick proclaimed that untangling the molecular strands of the double helix had revealed “the secret of life”. As Elixir vividly explains, Crick was wrong: the intriguing puzzle of life’s crystallin­e asymmetry remains unresolved.

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