Is this the end for wrin­kles?

Sci­en­tists ‘re­verse skin cell dam­age’

Daily Mail - - Brexit In Crisis - By Colin Fer­nan­dez Sci­ence Cor­re­spon­dent

THERE may never be a cure for grow­ing old. But we’re al­ready one step closer to age­less­ness – in looks at least.

Wrin­kles could van­ish with the help of drugs that boost pro­duc­tion of young skin cells, ac­cord­ing to sci­en­tists.

A re­search team has iden­ti­fied a pro­tein which it says is vi­tal to look­ing young. As fewer new cells con­tain­ing it are born, the skin ap­pears mis­shapen, thin­ner and blotchy.

Now they say two drugs that boost lev­els of the pro­tein – called COL17A1 – could pro­vide an ‘anti-age­ing in­ter­ven­tion’ that makes wrin­kles sig­nif­i­cantly less pro­nounced.

Over time, fewer strong skin cells con­tain­ing the pro­tein are born – mean­ing weaker ones take over and our skin de­vel­ops a wrinkly ap­pear­ance. Stress and sun dam­age can also re­duce pro­tein lev­els.

Emi Nishimura of Tokyo Med­i­cal and Den­tal School and col­leagues have now dis­cov­ered two chem­i­cals that boost lev­els of COL17A1 and stim­u­late pro­duc­tion of young skin cells which can dis­place older ones. The find­ing ‘points to­wards di­rec­tions for fa­cil­i­tat­ing skin re­gen­er­a­tion and re­duc­ing skin age­ing,’ the au­thors wrote.

As well as their re­ju­ve­nat­ing ef­fect, the chem­i­cals Y27632 and apoc­ynin could also help wounds heal and even pre­vent skin can­cer, their re­port said.

Re­spond­ing to the find­ings, Ganna Bilusova and James DeGre­gori, both of the Univer­sity of Colorado, sug­gest higher pro­tein lev­els could stop tu­mours form­ing ‘ be­cause these fit cells com­pete with (and elim­i­nate) both dam­aged stem cells and tu­mour-prone cells’. The study, which ap­pears in jour­nal Na­ture, was based on re­search us­ing mice and hu­man skin grown in a lab­o­ra­tory. The chem­i­cals have not been tested on liv­ing hu­mans.

Newspapers in English

Newspapers from UK

© PressReader. All rights reserved.