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DEFENDER Rob Holding (ruptured anterior cruciate ligament) is expected to be out of the Gunners line up for between six and nine months. Midfielder Aaron Ramsey (ankle) is a doubt and Mesut Ozil (back) is unlikely to feature once more, but Granit Xhaka is available following suspension. HUDDERSFIELD will be without suspended pair Steve Mounie and Philip Billing. Striker Mounie misses the second game of a three-match ban following his red card against Brighton and midfielder Billing sits out after reaching five yellow cards. Defender Chris Lowe could feature after recovering from a shoulder injury.
Last season: Arsenal 5 Huddersfield 0
Top scorers: P-E Aubameyang (Arsenal) 10; M Jorgensen & A Mooy (Huddersfield) 2
Referee: Paul Tierney
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BOURNEMOUTH will be without England midfielder Lewis Cook for the rest of the season because of a serious knee injury. Midfielder Dan Gosling will miss the Liverpool game with his own knee problem. Defender Adam Smith (knee) continues his rehabilitation.
LIVERPOOl boss Jurgen Klopp is without Sadio Mane (foot), Dominic Solanke (groin), Dejan Lovren (concussion), Joe Gomez (broken leg) and Nathaniel Clyne (muscle). Left-back Andy Robertson will return.
Last season: Bournemouth 0 Liverpool 4
Top scorers: C Wilson (Bournemouth) 8; M Salah (Liverpool) 7
Referee: Lee Mason
BURNLEY midfielder Steven Defour is touch and go after picking up a knee problem against Crystal Palace last weekend. The same knee kept him out for more than six months previously, but the Clarets are hopeful it is nothing serious. BRIGHTON will check on forward Glenn Murray (shoulder) and winger Jose Izquierdo (knee) before kick off. Midfielder Dale Stephens is available again after completing a three-match ban, but defender Shane Duffy will now start a ban following a red card against Fulham. Forward Alireza Jahanbakhsh is back in training but not ready to play.
Last season: Burnley 0 Brighton 0
Top scorers: S Vokes (Burnley) 3; G Murray (Brighton) 8
Referee: Martin Atkinson
CARDIFF have problems up front for this crunch Premier League relegation clash. Kenneth Zohore is out with a calf injury while Gary Madine and Danny Ward are also nursing knocks. Makeshift striker Callum Paterson will lead the line again. Nathaniel Mendez-Laing is chasing a first start since damaging knee ligaments in August. MICHAEL Obafemi remains a fitness doubt for Southampton. The Republic of Ireland teen striker continues has a hamstring problem. New boss Ralph Hasenhuttl will take charge of his first Saints match.
Last season: No Corresponding fixture
Top scorers: C Paterson & J Murphy (Cardiff) 3; D Ings (Southampton) 4
Referee: Jonathan Moss
JORGINHO and David Luiz are expected to return to Chelsea’s starting line-up. Blues boss Maurizio Sarri is expected to restore his first-choice side after Wednesday’s loss at Wolves, a second defeat in three league games. Mateo Kovacic could start in midfield and Olivier Giroud may come in up front. CITY pair Sergio Aguero and Kevin De Bruyne have been ruled out. Striker Aguero has a muscular problem while the game comes too early for playmaker De Bruyne (knee) after a month out. Left-back Benjamin Mendy (knee) and goalkeeper Claudio Bravo (Achilles) are long-term casualties.
Last season: Chelsea 0 Man City 1
Top scorers: E Hazard (Chelsea) 7; S Aguero (Man City) 8
Referee: Michael Oliver
MAN WITH THE IRON FISTS: Mike Tyson looked invincible at one stage in his career