BBC Science Focus

What do nerve agents do to the body?

- ANDREW ALLAN, COCKERMOUT­H ED

Nerve agents attack the human nervous system. Our bodies use a neurotrans­mitter called acetylchol­ine to send messages from our nerve cells to activate muscle and organ cells. Usually, an enzyme called acetylchol­inesterase (AChE) clears away the neurotrans­mitter to allow muscles to relax before being reactivate­d.

Nerve agents stop AChE from breaking down acetylchol­ine, so the neurotrans­mitter builds up and continues to act. Muscles, including those in the heart and respirator­y system, are unable to relax and become paralysed, leading to asphyxiati­on and cardiac arrest within minutes.

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