...7 UP AND BIPO­LAR DIS­OR­DER?

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1.

The orig­i­nal for­mula for 7 Up was created in 1929 by Charles Leiper Grigg. It was ini­tially mar­keted as a patent medicine, like many soft drinks dur­ing the Great De­pres­sion.

2.

The ‘lemon-lime soda’ con­tained lithium cit­rate, and al­though Grigg never con­firmed the ori­gin of the name ‘7 Up’, one the­ory is that the num­ber 7 refers to the atomic mass of lithium.

3.

Lithium cit­rate was known to be a mood­sta­bil­is­ing drug (lithium tablets are shown on the left), and the drink was sold as a pick-me-up and hang­over cure. An early ver­sion of Coca-Cola also con­tained lithium cit­rate.

4.

The drug was re­moved from 7 Up in 1948, but lithium com­pounds are still used today to treat bipo­lar dis­or­der (im­age of bipo­lar brain can be seen on the right). They strengthen con­nec­tions in the brain re­gions that reg­u­late mood and behaviour.

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