BBC Science Focus

EATING MARMITE COULD EASE ANXIETY AND DEPRESSION

B vitamins found in the spread may help the brain produce calming neurochemi­cals

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“Vitamin B6 helps the body produce a specific chemical messenger that inhibits impulses in the brain”

Sorry, haters, here’s yet another reason to love Marmite: vitamin B6 – a nutrient found in abundance in the yeast extract – may help to reduce feelings of anxiety and depression, a study carried out by researcher­s at the University of Reading has found.

The team gathered together a group of nearly 500 volunteers aged between 18 and 58, 265 of whom had self-reported anxiety and 146 had self-reported depression. They then split them into three subgroups. One group was given 100mg doses of vitamin B6 supplement­s every day for a month, a second received 1mg doses of B12 supplement­s, and a final group got a placebo.

The researcher­s also had all participan­ts complete questionna­ires designed to assess mood and feelings throughout the study. They found that the participan­ts who took vitamin B6 reported feeling less anxious and depressed after taking the supplement­s.

While previous studies have suggested that consuming Marmite may help to reduce feelings of anxiety and depression, exactly which nutrients were responsibl­e for the effect remained unclear until now.

The team found that the calming effect was likely due to vitamin B6 increasing the body’s production of gamma-aminobutyr­ic acid (GABA), a neurotrans­mitter that inhibits impulses between nerve cells in the brain.

“The functionin­g of the brain relies on a delicate balance between the excitatory neurons that carry informatio­n around and inhibitory ones, which prevent runaway activity,” said lead author Dr David Field, of the University of Reading. “Recent theories have connected mood disorders and some other neuropsych­iatric conditions with a disturbanc­e of this balance, often in the direction of raised levels of brain activity. Vitamin B6 helps the body produce a specific chemical messenger that inhibits impulses in the brain, and our study links this calming effect with reduced anxiety among the participan­ts.”

Don’t worry if you fall into the haters’ camp. Vitamin B6 can also be found in tuna, chickpeas and many different fruits and vegetables. However, the doses used in the study are much higher than the amount that could typically be consumed from food, the researcher­s caution.

“It is important to acknowledg­e that this research is at an early stage and the effect of vitamin B6 on anxiety in our study was quite small compared to what you would expect from medication,” said Field.

“However, nutrition-based interventi­ons produce far fewer unpleasant side effects than drugs, and so in the future people might prefer them as an interventi­on.

“Further research is needed to identify other nutritionb­ased interventi­ons that benefit mental wellbeing, allowing different dietary interventi­ons to be combined in future to provide greater results.”

 ?? ?? Happy chemicals: crystals of vitamin B6, as viewed under a microscope
Happy chemicals: crystals of vitamin B6, as viewed under a microscope

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