BBC Science Focus

WHY EVERYTHING YOU KNOW ABOUT WEIGHT LOSS IS WRONG

When it comes to fat, there’s no ‘one-size-fits-all’ approach

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Recently, I was interviewe­d by Steven Bartlett on the Diary Of A CEO podcast about my work on obesity. While I’ve done a gazillion previous podcasts, either as host or guest, this one stood out for three reasons: first, the interview was long-form and was released in its entirety; second, in addition to the audio recording, it was filmed with multiple cameras, and posted online; and third, the scale of the audience. I’m not sure how many listeners tuned in to the actual podcast, but at time of writing, 2.5 million(!!) people had viewed the ‘feature-length’ interview on YouTube.

What soon became clear was, of the millions that watched, many felt the need to comment loudly on social media (while tagging and @-ing me) on my appearance, vis-à-vis my expertise in obesity. I am, shall we say, not at my ‘fighting weight’, having gained more than four kilos during the past few COVID years. This, coupled with my sartorial error of appearing in a roll-neck sweater (although in my defence I was not expecting to be filmed), resulted in comments like, “Why would you trust a man with moobs about weight and nutrition?” Ouch.

This got me thinking, though. If I, a slightly squashy middle-aged professor, was on the receiving end of such comments, what horrors must someone with obesity be facing on a daily basis? It is interestin­g that if I were to negatively comment on someone’s gender, sexual orientatio­n or ethnicity in public, I would rightly lose my job. Yet today, many feel it appropriat­e to comment on someone’s size or shape. Weight stigma is rife. It’s not only cruel, but counterpro­ductive, yet ubiquitous in society. It has led to the emergence of the body-positivity movement.

‘Body positivity’ was founded on the belief that all of us should have a positive body image, and advocates the acceptance of all bodies, regardless of physical ability, size, gender, race or appearance, and I understand its emergence as a protest to ‘fat-shaming’. I fear, however, that some have gone too far with regards to the ‘health at every size’ messaging, and are ignoring the science. What is unequivoca­l, and please don’t shoot the messenger, is that carrying too much fat is bad for your health.

So why is carrying too much fat bad? In large part, people misunderst­and what happens when they gain or lose weight; they think that they are gaining fat cells or losing fat cells. This is not true. You have to consider your fat cells like balloons; they get bigger when you gain weight, and smaller when you lose weight. The actual number of fat cells doesn’t change by much. The safest place to store fat is in fat cells. Like balloons, fat cells will expand until they can’t expand any more. This is when the trouble begins, because once our fat cells are full, the fat has to go somewhere else, and ends up in our muscles or our liver, for example. While these are designed to store some fat, too much of it begins to adversely affect their function, in a phenomenon known as ‘lipotoxici­ty’, literally meaning fat poisoning. Thus, when we are carrying more fat than we can safely store, that is when we tilt into diseases such as type 2 diabetes, heart disease and certain cancers.

But how much is too much fat? Here is the interestin­g thing: depending on our biology, our fat cells are able to expand to different sizes before becoming full. So East Asians (such as Chinese folk like me) and South Asians (such as Indians, Pakistanis and Bangladesh­is) don’t have to put on that much weight before increasing their risk of getting type 2 diabetes. Whereas others, including white people and, famously, Polynesian­s, can gain a lot more weight before becoming ill, in large part, due to the expandabil­ity of their fat cells.

The degree to which our fat cells can expand has powerful genetic influences and informs our differing safe fat-carrying capacities. So there is most definitely health present at many sizes, with some larger folk being metabolica­lly healthy, and lean people with type 2 diabetes. But here is the critical take-home message: for any given individual, there cannot be health at every size, because if you surpass your own safe fat-carrying capacity, you WILL become ill. I am not saying this to be body negative, and I am certainly not judging or blaming anyone who chooses not to lose weight, or who has tried and been unsuccessf­ul. I am simply stating a crystal-clear biological fact.

In a mature society, we should be able to hold two thoughts in our head simultaneo­usly; that living with obesity is not healthy, and those with obesity are not to blame. The ability to someone’s safe fat-carrying capacity is the subject of genetic and biological research, and would transform the way we consider the definition of ‘obesity’ and who actually needs to lose weight.

“For any given individual, there cannot be health at every size”

 ?? ?? PROF GILES YEO (@GilesYeo)
Giles is a professor of molecular neuroendoc­rinology at the University of Cambridge, whose research focuses on food intake, diabetes and obesity. His latest book is
Why Calories Don’t Count (£14.99, Orion Spring).
PROF GILES YEO (@GilesYeo) Giles is a professor of molecular neuroendoc­rinology at the University of Cambridge, whose research focuses on food intake, diabetes and obesity. His latest book is Why Calories Don’t Count (£14.99, Orion Spring).

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