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Bust­ing brain blood flow bar­ri­ers in neu­rode­gen­er­a­tive dis­eases

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While the brain is vastly com­plex, there is still much more to ex­plore and un­der­stand about this or­gan and neu­rode­gen­er­a­tive dis­eases that can oc­cur. The ad­e­quate flow of blood to and from the brain is vi­tal for the proper func­tion­ing of our bod­ies and minds. Via a net­work of cap­il­lary ves­sels in our bod­ies, tis­sues and or­gans

(in­clud­ing the brain) are sup­plied with oxy­gen and nu­tri­ents.

But when blood flow is blocked for any rea­son, such as a build­ing up of white blood cells, cer­tain neu­rode­gen­er­a­tive dis­eases can seem to si­mul­ta­ne­ously arise. Could re­duced blood flow play a role in the on­set of these dis­eases?

At the Meinig School of Biomed­i­cal En­gi­neer­ing at Cor­nell Univer­sity, Oliver Bracko, PhD stu­dent Nancy Ruiz and col­leagues in­ves­ti­gate the im­por­tant role that brain blood flow plays in the con­text of neu­rode­gen­er­a­tive con­di­tions, such as de­men­tia - which af­fects around 50 mil­lion world­wide.

 ??  ?? Top, right: 3D ren­der­ing of blood ves­sels of the brain.
Di­rectly right: Cor­ti­cal brains sec­tion, Astro­cytes (green), Mi­croglia (red), amy­loid-beta plaques.
All: © Oliver Bracko. All rights re­served.
Top, right: 3D ren­der­ing of blood ves­sels of the brain. Di­rectly right: Cor­ti­cal brains sec­tion, Astro­cytes (green), Mi­croglia (red), amy­loid-beta plaques. All: © Oliver Bracko. All rights re­served.

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