Scottish Daily Mail

Male pill is a step closer ... but would you trust him?

- By Fiona MacRae Science Editor

A CONTRACEPT­IVE pill for men is a step closer after scientists identified a protein that is key to male fertility.

Without it, sex is possible but pregnancy is not. The team behind the breakthrou­gh believe it could be the key to the male pill.

While oral contracept­ives for women have been on offer for more than 50 years, men’s only options are condoms and vasectomie­s.

A male pill would liberate women from the burden of family planning, as well as meaning they were not exposed to the hormones in oral contracept­ives.

The research, in journal Science, could provide insight into causes of male infertilit­y. However, it remains to be seen whether women would trust men to take the pill.

The scientists at Osaka University, Japan, found a protein called calcineuri­n is vital for sperm to swim properly and break their way into the egg. Tests found male mice lacking the protein – which humans also have – could mate but females did not become pregnant.

Professor Masahito Ikawa said: ‘The developmen­t of a drug that specifical­ly inhibits sperm calcineuri­n may be the long soughtafte­r reversible male contracept­ive that works in a short time-span. But would women trust men to take it? Perhaps not. Don’t make love with a person you cannot trust.’

As the drug would not be based on hormones, it should not interfere with the man’s sex drive. Professor Mike Wyllie, of reproducti­ve health company Repros Inc, said: ‘Although a drug based on the approach is many years off, this could represent a viable approach to male contracept­ion based on a substantia­l reduction in sperm function.’

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