Hopes for new breast can­cer treat­ment

The Courier & Advertiser (Angus and The Mearns Edition) - - NEWS -

Sci­en­tists have linked more than 100 genes to an in­creased risk of breast can­cer – pav­ing the way for more per­son­alised treat­ments, a study has said.

A team at The In­sti­tute of Can­cer Re­search in Lon­don iden­ti­fied a “trea­sure trove” of spe­cific genes in­volved in rais­ing a woman’s risk of de­vel­op­ing the con­di­tion.

They also linked 32 genes to the length of time a woman sur­vived the dis­ease.

In the fu­ture, test­ing for these genes could help iden­tify the women most at risk or could be ex­plored as tar­gets for new drugs, the re­searchers said.

Pro­fes­sor Paul Work­man, chief ex­ec­u­tive of The In­sti­tute of Can­cer Re­search, said: “Large-scale ge­nomic stud­ies have been in­stru­men­tal in as­so­ci­at­ing ar­eas of our DNA with an in­creased risk of breast can­cer.

“This study brings these re­gions of DNA into sharper fo­cus, un­cov­er­ing a trea­sure trove of genes that can now be in­ves­ti­gated in more de­tail.

“The ways in which par­tic­u­lar genes in­flu­ence can­cer risk are highly com­plex.

“In the fu­ture, a bet­ter un­der­stand­ing of the genes iden­ti­fied in this study could lead to the dis­cov­ery of new tar­geted drugs, or new strate­gies to im­prove di­ag­no­sis or pre­ven­tion of the dis­ease.”

The study, pub­lished in the jour­nal Na­ture Com­mu­ni­ca­tions, used a new ge­netic tech­nique to an­a­lyse which genes in­ter­acted with 33 DNA re­gions known to af­fect breast can­cer.

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