Experts say common painkillers could help to curb depression

Common painkillers may help curb depression, especially if taken with antidepressants, experts say.

A new review found that antiinflammatory agents, including painkillers such as ibuprofen and aspirin, as well as statins and omega 3 fish oils, could curb major symptoms of depression.

Experts from the University of Science and Technology in Wuhan, China, reviewed 26 studies for their work in the Journal of Neurology, Neurosurgery and Psychiatry.

The anti-inflammatories included in the studies were non-steroidal anti-inflammatory drugs (NSAIDS) such as ibuprofen and aspirin; omega 3 fatty acids; cytokine inhibitors; statins; steroids; antibiotics; a drug used to treat sleep disorders (modafinil); and N-acetyl cysteine, which is used to loosen excess phlegm in people with cystic fibrosis.

The results suggested that, overall, these medicines and agents were 52% more effective than placebo at reducing overall symptoms of depression and were 79% more effective in eliminating symptoms than placebo.

The most effective drugs were found to be NSAIDS, omega 3 fatty acids, statins and minocyclines, and the effect was greater if these were added to antidepressants.

However, there was no clear link with improved quality of life, although this may have been due to the small number of studies that examined this, the researchers said.

They concluded: “The results of this systematic review suggest that anti-inflammatory agents play an antidepressant role in patients with major depressive disorder and are reasonably safe.”

Professor David Curtis, honorary professor at University College London, said he was not convinced by the findings.

He added: “It is quite misleading to describe the use of antiinflammatory agents as safe.

“The most effective antiinflammatory agents used were NSAIDS and although problems are rare, every year thousands of people die from the side-effects of these medications, which are usually taken for chronic pain and are especially risky if taken for long periods of time.”