Probe into liver damage caused by paracetamol

Findings could inform further research into ways of counteracting it

Scientists claim to have shed new light on how the common painkiller paracetamol causes liver damage.

They believe their findings could inform further research into therapies to counteract the harm caused by excessive doses of the drug – the leading cause of acute liver failure in the western world.

Poisoning caused by too much paracetamol can be difficult to treat and may even prove fatal.

Scientists at Edinburgh University studied the impact of the painkiller on liver cells in human and mouse tissue.

Their tests showed that in certain settings, paracetamol can damage the liver by harming the vital structural connections between adjacent cells in the organ.

When these cell wall connections, known as tight junctions, are disrupted, the liver tissue structure is damaged, the cells are unable to function properly and they may die.

Scientists said this type of cell damage was known to occur in liver conditions including hepatitis, cirrhosis, and cancer, but has not been linked to paracetamol toxicity until now.

Researchers say they will now seek to examine how varying paracetamol doses and timescales affects toxicity in the liver, and identify potential targets for new drugs.

Dr Leonard Nelson, of the university’s Hepatology Laboratory and Institute for Bioengineering, who co-led the study, said: “Paracetamol is the world’s preferred pain remedy – it is cheap and considered safe and effective at therapeutic dose.

“However, drug-induced liver damage remains an important clinical problem and a challenge for developing safer drugs.”

He continued: “Our findings reinforce the need for vigilance in paracetamol use, and could help discover how harm caused by its adverse use might be prevented.”