Ibuprofen link to risk of suffering cardiac arrest

Researchers find that taking painkiller that can be bought over the counter increases chances by almost a third

One of the most popular over-thecounter painkillers in the UK can heighten the chances of suffering a potentially fatal cardiac arrest, a study has shown.

Researchers in Denmark found that taking ibuprofen was associated with a 31% increased risk of the emergency condition, which occurs when the heart suddenly stops pumping blood.

Other medicines from the same family of painkillers, known as nonsteroidal anti-inflammatory drugs (NSAIDs), posed a similar danger, according to the findings.

They included diclofenac, which raised the risk by 50%, and was available over the counter in the UK until 2015. Today, it can only be obtained on prescription.

Heart expert Professor Gunnar Gislason, who led the study, called for tighter controls on NSAIDs.

He said: “Allowing these drugs to be purchased without a prescription, and without any advice or restrictions, sends a message to the public that they must be safe. The findings are a stark reminder that NSAIDs are not harmless.

“Diclofenac and ibuprofen, both commonly used drugs, were associated with significantly increased risk of cardiac arrest.

“NSAIDs should be used with caution and for a valid indication. They should probably be avoided in patients with cardiovascular disease or many cardiovascular risk factors.

“I don’t think these drugs should be sold in supermarkets or petrol stations where there is no professional advice on how to use them.

“Over-the-counter NSAIDs should only be available at pharmacies, in limited quantities and in low doses.”

“The current message being sent to the public about NSAIDs is wrong.

“If you can buy these drugs in a convenience store then you probably think ‘they must be safe for me’.

“Our study adds to the evidence about the adverse cardiovascular effects of NSAIDs and confirms that they should be taken seriously and used only after consulting a healthcare professional.”

The most common cause of a cardiac arrest is a life-threatening abnormal heart rhythm called ventricular fibrillation (VF).

It causes electrical activity in the heart to become so chaotic that the organ ceases to pump rhythmically and quivers or “fibrillates” instead. Without immediate treatment to keep the circulation going, death occurs in minutes.

Sales of over-the-counter painkillers amounted to almost £600 million in the UK in 2015, according to The Pharmaceutical Journal.

The Danish investigators studied data on all patients who had an out-of hospital cardiac arrest in the country between 2001 and 2010.