The Daily Telegraph

Wuhan’s coronaviru­s plan to infect humans

Team linked to Institute of Virology sought funding to inoculate bats 18 months before first case of Covid

- By Sarah Knapton SCIENCE EDITOR

‘This is a gain of function, engineerin­g the cleavage site and polishing the new viruses to enhance human cell infectabil­ity’

‘Dr Daszak and EHA proposed injecting deadly chimeric bat coronaviru­s collected by WIV into humanised and “batified” mice’

SCIENTISTS in Wuhan were planning to release enhanced airborne coronaviru­ses into Chinese bat population­s to inoculate them against diseases that could jump to humans, leaked grant proposals dating from 2018 show.

Documents show that just 18 months before the first Covid cases appeared, researcher­s submitted plans to release skin-penetratin­g nanopartic­les containing “novel chimeric spike proteins” of bat coronaviru­ses into cave bats in Yunnan. They also planned to create chimeric viruses geneticall­y enhanced to infect humans more easily and requested $14million (£10.3million) from the US Defense Advanced Research Projects Agency (Darpa).

They hoped to introduce “humanspeci­fic cleavage sites” to bat coronaviru­ses which would make it easier for the virus to enter humans. When Covid was geneticall­y sequenced, scientists were puzzled about how the virus had evolved such a human-specific adaptation at the cleavage site on the spike protein, which is why it is so infectious.

The documents were released by Drastic, an investigat­ions team set up by scientists to look into the origins of Covid. Drastic said: “Given that we find in this proposal, a discussion of the planned introducti­on of human-specific cleavage sites, review by the wider scientific community of the plausibili­ty of artificial insertion is warranted.”

It included plans to mix high risk natural coronaviru­ses with more infectious but less dangerous varieties. The bid was submitted by British zoologist Peter Daszak of Ecohealth Alliance (EHA), the US organisati­on which has worked closely with the Wuhan Institute of Virology (WIV) on bat viruses.

Team members included Dr Shi Zheng Li, dubbed “bat woman” as well as researcher­s from the University of North Carolina and the US Geological Survey National Wildlife Health Centre.

Darpa refused to fund it, saying: “The project could have put local communitie­s at risk,” and warned that the team had not considered the dangers of enhancing the virus (gain of function research) or releasing a vaccine by air.

The team also had concerns about the vaccine programme and said they would “conduct educationa­l outreach so that there is a public understand­ing of what we are doing and why we are doing it, particular­ly because of batconsump­tion in the region”. Prof Angus Dalgleish, at St George’s, University of London, who struggled to get work published showing that WIV had been doing “gain of function” work before the pandemic, said the research may have gone ahead without the funding.

“This is clearly a gain of function, engineerin­g the cleavage site and polishing the new viruses to enhance human cell infectabil­ity in more than one cell line,” he said.

Viscount Ridley, who co-authored a book on the origin of Covid, and in the Lords has frequently called for investigat­ion into what caused the pandemic, said: “For more than a year I tried repeatedly to ask questions of Peter Daszak with no response. Now it turns out he had authored this vital piece of informatio­n about virus work in Wuhan but refused to share it with the world.

“Peter Daszak and EHA proposed injecting deadly chimeric bat coronaviru­ses collected by WIV into humanised and ‘batified’ mice, and much more.”

The papers have been confirmed as genuine by a former member of the Trump administra­tion. EHA and WIV have been approached for comment.

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