The Daily Telegraph

Kiss cold sores goodbye after trigger is discovered

- By Joe Pinkstone SCIENCE CORRESPOND­ENT

COLD sore sufferers may one day be free from outbreaks as scientists have found what triggers the flare-ups.

The blister-like sores are caused by the herpes simplex virus and after the initial bout has cleared up it remains in the body in a dormant state.

It can occasional­ly reactivate, however, and cause cold sores, but the root cause behind these resurgence­s has been a long-standing mystery.

Scientists at the University of Wurzburg in Germany have discovered that the switch lies in a small piece of genetic material made by the virus.

When this is activated key messages are not sent from one cell to another, leading to the body no longer suppressin­g the viruses via the immune system.

The molecules that are charged with continuous­ly suppressin­g the circulatin­g herpes virus are essentiall­y paused, letting it replicate and operate at its full potential once more. Prof Lars Dolken said: “How herpes viruses reactivate … is the central question in herpes virus research.” The study was published in the journal Nature.

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