Eyes have it as reactions to changes in light intensity reveal link to autism
BABIES whose pupils react more strongly to sudden changes in light intensity are more likely to later be diagnosed with autism spectrum disorder (ASD), a study has shown.
Researchers from Birkbeck, University of London, said their findings provide support for the view that sensory processing plays an important role in the development of the disorder.
The study saw them investigate the pupillary light reflex – a basic mechanism controlling the amount of light that reaches the retina in which the pupil contracts when the eye is exposed to sudden increases in brightness.
The participants, from the UK and Sweden, were 10 months old when their pupillary responses to light were first examined with an eye-tracker that measured these changes in pupil size.
They were followed until they were three years of age, at which point they took part in a diagnostic evaluation.
Those infants who eventually fulfilled criteria for ASD showed a stronger pupillary response than infants who did not later fulfil ASD criteria.
The amount of pupil constriction in infancy was also associated with the strength of autism symptoms at three years old.
Across the two countries, the study looked at 147 infants with an older sibling with ASD.
Of these, 29 met the criteria for ASD at the follow-up. The study also included a control group of 40 typically developing infants.