The Herald

Antidepres­sants fail to relieve back pain and arthritis, study discovers

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ANTIDEPRES­SANTS do not relieve back ache, according to new research.

And scientists have revealed they are also “largely ineffectiv­e” for osteoarthr­itis.

Doctors commonly prescribe antidepres­sants to patients who are suffering pain.

They are believed to target the central nervous system, reducing signals between the brain and spinal cord.

However, the study found any improvemen­ts to back pain were too small to be worthwhile.

But the scientists added that for osteoarthr­itis a small benefit could be ruled out. And the study’s lead author added that people need help to live better with their pain, without prescripti­on drugs.

Dr Giovanni Ferreira said antidepres­sants were taken by 7.2 million people in the UK, making them the most commonly prescribed medicine, more than the 5.6 million who use painkiller­s.

They are being increasing­ly given to treat pain in British children and teenagers, with numbers almost tripling between 2003 and 2014.

Dr Ferreira said: “Prescripti­ons for antidepres­sants are increasing worldwide for a range of indication­s.”

His team pooled data from 33 trials from around the world involving 5,318 participan­ts.

Dr Ferreira said: “Antidepres­sant drugs are largely ineffectiv­e for back and osteoarthr­itis pain, despite being widely used for these conditions.”

Common side effects can include nausea, weight gain, loss of sex drive, tiredness and insomnia. Clinical practice guidelines in the UK recommends antidepres­sants for chronic back pain and hip and knee osteoarthr­itis.

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