The Mail on Sunday

Blast to the kidney can end high blood pressure – for good

- By Pat Hagan

AREVOLUTIO­NARY 60- minute therapy for high blood pressure could allow patients to t hrow their tablets away for good. The unlikely remedy involves blasting nerves in the kidneys with sound waves to stop them sending signals to the brain that drive up blood pressure.

It could slash the risk of heart attacks and strokes, two of Britain’s biggest killers.

New research reveals the treatment, called renal denervatio­n, keeps high blood pressure at bay in almost 60 per cent of volunteers.

More than a third are able to stop taking their prescripti­on medicines altogether, while others could take fewer pills – reducing the risk of side effects ranging from diarrhoea and dizziness to headaches and fatigue.

In 2016, NHS England ruled there was insufficie­nt evidence to make renal denervatio­n widely available on the health service.

It’s not yet clear whether the new findings will lead to a change in that rule, but professor Melvin Lobo, who led the study at Queen Mary University of London and Barts Health NHS Trust, said the results could transform treatment for high blood pressure.

He said: ‘ This could soon be offered as an alternativ­e to lifelong medication. We know from research that this kind of treatment can be effective for at least three years.

‘It’s too early to say it’s a permanent cure but we certainly expect the benefits to be long-lasting.’

Blood pressure is a measure of the force exerted on the walls of the arteries by blood flow. The higher the pressure, the harder the heart i s working to pump blood, putting the muscle under added strain.

The i ncreased pressure also damages blood vessel walls, so they’re prone to forming clots, which can lead to a heart attack or stroke.

High blood pressure, or hypertensi­on, affects one in five adults in the UK and is thought to be responsibl­e for half of all heart attacks and strokes.

It is estimated that more than half of all patients on medication are still poorly controlled.

The kidneys remove toxins and waste products from the blood, which is excreted as urine. But they are also integral in regulating bl ood pressure, r el easi ng an enzyme that interacts with other hormones in the body to cause blood vessels to contract. In healthy people this raises blood pressure to normal levels, but if too much of the enzyme is released, blood pressure becomes permanentl­y high.

By damaging t he nerves in the kidneys, this process can be ‘switched off’, helping return blood pressure to manageable levels.

The procedure is carried out under local anaestheti­c, with a long, thin tube, called a catheter, inserted into an artery in the groin. Doctors use X-ray images to navigate through the body until the tip of the tube is located close to nerves in the walls of blood vessels attached to the kidney.

A thin wire is then fed through the catheter and, at the press of a button, high-energy sound waves are generated to heat up and destroy nerves in the firing line.

The whole process takes just under an hour because doctors usually need to zap at least half a dozen different points to destroy as m many nerve endings as possible.

Patients are normally allowed h home the same day.

There is a small risk of bleeding a and bruising and the nerves can grow back, al t hough t hey no g lo longer gl

send faulty messages. Blood pressure ppdb but should will return also to continue a healthy to level rise during times of stress or anxiety, once this subsides.

The latest investigat­ion, published in the journal Circulatio­n, looked at 140 UK patients who f failed to get better on drugs alone.

Six months after renal denervatio­n, 58 per cent still had healthy readings through a combinatio­n of the nerve-zapping treatment and reduced reliance on daily pills.

The treatment also seems to improve the body’s response to medication. Almost 36 per cent had been able to quit taking tablets completely.

Neil Boughton, 59, from Watford, had the treatment in December 2017 after suffering with high blood pressure for years.

Doctors first noticed he had high readings during routine medical checks when he was in his late 30s. His GP prescribed daily tablets but these made little or no difference.

In 2017 father-of-two Neil, who is a train driver, spotted a newspaper advertisem­ent recruiting volunteers with a history of high blood pressure for a new clinical trial involving renal denervatio­n.

He said: ‘The procedure was relatively quick and pain-free. I am taking a very low dose of bloodpress­ure medication but more than a year later, my readings are still well within the healthy range.

‘It’s given me real peace of mind about my future heart health.’

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