The Mail on Sunday

WHAT’S THE DIFFERENCE . . .

. . . between a virus and a retrovirus?

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VIRUSES are microscopi­c organisms that can enter and infect another organism. They are, in essence, parasites: they cannot survive for long outside a host. Most ordinary viruses, including SARS-CoV-2, enter the host’s cells and use them to replicate, destroying the cell in the process and causing damage and disease.

Retrovirus­es, such as the HIV virus, do not destroy the host’s cells but inject their genetic material into them. This combines with the genetic material already inside, turning the cell into a mini-factory pumping out new copies of the retrovirus. Retrovirus­es can quickly mutate, with new viral variants existing within a single host. This makes it very difficult to find effective treatments.

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