The Scotsman

Lack of sleep in middle age is linked to dementia risk

- By NINA MASSEY

Regularly sleeping six hours or fewer per night during middle age may be associated with a greater risk of dementia, according to a new study.

Researcher­s say their findings cannot establish cause and effect, but suggest a link exists between sleep duration and dementia risk.

The study suggests there is a higher risk of dementia in those sleeping six or fewer hours per night at the age of 50 to 60. Writing in Nature Communicat­ions, the authors say: "Here we report higher dementia risk associated with a sleep duration of six hours or less at age 50 and 60, compared with a normal (seven-hour) sleep duration."

Regularly sleeping six hours or fewer per night during middle age may be associated with a greater risk of dementia, according to a new study.

Researcher­s say their findingsca­n not establish cause and effect, but suggest a link exists between sleep duration and dementia risk.

The study suggests there is a higher risk of dementia in those sleeping six or fewer hours per night at the age of 50 to 60.

There was also a 30 per cent increased dementia risk in those with consistent­ly short sleeping patterns from middle to older age (from 50 to 70 years), irrespecti­ve of cardiometa­bolic or mental health issues (known risk factors for dementia).

Writing in Nature Communicat­ions, the authors say: "Here we report higher dementia risk associated with asleep duration of six hours or less at age 50 and 60, compared with a normal (seven-hour) sleep duration, although this was imprecisel­y estimated for sleep duration at age 70."

They add: "These findings suggest that short sleep duration in mid life is associated with an increased risk of late-onset dementia."

The study indicates that sleep may be important for brain health in midlife, and future research may be able to establish whether improving sleep habits may help prevent dementia. Nearly 10 million new cases of dementia are reported worldwide every year.

A common symptom is altered sleep, but researcher­s say there is growing evidence to suggest sleep patterns before dementia onset may contribute to the disease. while time spent sleeping is linked to dementia risk in older adults (65 years and older), it is unclear whether this associatio­n is also true for younger age groups.

Severine Sabia, from the University of Paris, and colleagues analysed survey data from UCL'S Whitehall II study that has examined the health of 7,959 British individual­s since 1985.Participan­tsself-reported their sleep duration, and some wore watch accelerome­ters overnight to confirm this was an accurate estimate.

The authors write: "Whether sleep parameters also affect late-life dementia remains the subject of debate.

"While incipient dementia is known to affect sleep-wake cycles, the extent to which sleep duration over the adult life course is associated with late-onset dementia is unclear because most studies have not explicitly considered age at assessment of sleep duration or the length of follow-up.

"Our approach pays attention to both these aspects along with inclusion of a wide array of covariates to show that short sleep duration in mid life is associated with an increased risk of dementia. Public health messages to encourage good sleep hygiene may be particular­ly important for people at a higher risk of dementia."

Dr Sara Imarisio, head of research at Alzheimer's R es earchuk, said :“while there is no sure-fire way to prevent dementia, there are things within our control that can reduce our risk. the best evidence suggests that not smoking, only drinking in moderation, staying mentally and physically active, eating a balanced diet, and keeping cholestero­l and blood pressure levels in check can all help to keep our brains healthy as we age."

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