Children with food allergies helped by new trial
Children given everyday foods to treat milk and peanut allergies are showing dramatic signs of improvement, according to early trial results.
Five NHS hospitals have so far joined a £2.5 million clinical trial, thanks to funding from the Natasha Allergy Research Foundation.
Natasha Ednan-laperouse died in 2016 after suffering a severe allergic reaction to sesame baked into a Pret baguette.
Her parents, Nadim and Tanya Ednan-laperouse, campaigned for a change in food laws and set up the foundation with the hope of curing allergies through research.
Now the new clinical oral immunotherapy (OIT) trial is using everyday foods to build up an allergy patient’s tolerance over time.
Foods are given under medical supervision and the trial is also training NHS staff to offer OIT treatment.
Sibel Sonmez-ajtai, paediatric allergy consultant and principal investigator at Sheffield Children’s NHS Foundation Trust, said: “This study is enabling us to do something we would never have dreamed of doing before – giving patients the foods we know they are allergic to.
“This treatment is not a cure for a food allergy, but what it achieves is life-transforming.
“To have a patient who has had anaphylaxis to 4mls of milk to then tolerate 90mls within six to eight months is nothing less than a miracle.”
Thomas Farmer, 11, who was diagnosed with a severe peanut allergy when he was one, can now eat six peanuts a day
after joining the trial in Southampton.
His mother Lauren said: “Having food allergies can be really difficult and isolating ... (but) our journey on the Natasha study has been amazing so far.
“At first, it was very scary for both Thomas and us when he did the food challenge, as we weren’t sure what to expect.
“Knowing that Thomas can now tolerate six peanuts a day
has taken away so much anxiety around food.
“It will also hopefully mean that he will be able to eat a wider variety of food as we won’t be so concerned about accidental exposure. For Thomas to be able to achieve all this with no medicine, just off-the-shelf foods, is amazing.”
Since joining the trial in Newcastle, five-year-old Grace Fisher, who has a milk allergy, is now drinking 120ml milk a
day. She will soon be able to eat pizza with her friends.
Her mother Emma said: “Grace is over six months into this journey and is doing amazing. She is currently on 120ml of milk and loves her daily hot chocolates.”
To date, 139 people aged from two to 23 with allergies to peanuts or cow’s milk have started treatment. The trial is being run at University Hospital Southampton NHS Foundation
Trust, Imperial College Healthcare NHS Trust, University Hospitals of Leicester NHS Trust, Newcastle Hospitals NHS Foundation Trust and Sheffield Children’s NHS Foundation Trust. It will shortly start in Scotland, with plans for Bristol and Leeds to also join.
If successful, the three-year trial could provide more evidence for everyday foods treatment to be made available on the NHS.
This treatment isnotacurebut what it achieves is life-transforming