The Scottish Mail on Sunday

‘Seed’ that ends need for a second breast cancer op

- By Jo Macfarlane

THOUSANDS of women undergoing breast cancer surgery could be spared repeated operations – thanks to a tiny magnetic ‘seed’ implanted into their tumour. The pioneering device, smaller than a grain of rice, acts as a marker, helping guide doctors to lumps within the breast that can’t otherwise be felt or seen.

At present, women requiring surgery for breast cancer have up to a 25 per cent chance of needing a follow-up operation. This is necessary if parts of the tumour are missed the first time around. But just six per cent of patients given the Magseed implant need a second procedure, as it helps improve accuracy during the initial operation.

The technique is set to replace the traditiona­l method used since the 1970s, which involves inserting a steel wire that ‘hooks’ on to the tumour on the morning of surgery.

This is uncomforta­ble and stressful for patients because the wire protrudes from the breast, and is easily dislodged. The wire can also move by several centimetre­s before surgery takes place, which means cancerous tissue is left behind and further surgery is needed to remove it completely.

However, the Magseed does not move at all, say experts. Surgeon James Harvey, at the University Hospital of South Manchester NHS Foundation Trust, is leading a UK-based trial of 1,000 women to compare the results of Magseed with the wire. He says: ‘The wire can be a particular­ly unpleasant experience for patients, and from a surgeon’s point of view it’s not unusual for it to be dislodged. It means a couple of times a year you can do an operation and later find you haven’t got any of the cancer lump in the specimen you’ve removed, which is awful for the patients.

‘Magseed definitely makes this more precise, so a surgeon can be confident they’re in the right place. It’s less stressful for patients, and everyone on the operating team is less stressed on the day of surgery because there’s no need to ferry patients around as much.’

About 55,000 new cases of breast cancer are diagnosed in the UK every year. However, improvemen­ts in screening mean many cases are being picked up earlier, before lumps can be felt.

Successful chemothera­py also means that some lumps shrink significan­tly before surgery.

This makes it even more crucial to accurately locate the tumours – sometimes just a tiny cluster of cancer cells – which may not be distinguis­hable from healthy tissue to the naked eye.

Magseed is being used in 28 hospitals across the country, while 15 more are evaluating it.

Patients are given a local anaestheti­c and the tumour is located using either ultrasound or mammogram. The 5mm Magseed, made from medical-grade steel, is then inserted through a long needle.

During the subsequent operation to remove the tumour, the surgeon uses a probe called Sentimag, which emits a magnetic field and makes a high-pitched sound when it comes closer to the seed.

Maria Rothwell, 51, from Sale, Greater Manchester, was diagnosed with aggressive breast cancer in January 2019. The former export clerk and keen cyclist was treated with chemothera­py ‘wonder drug’ Herceptin, which shrank her tumour from 3.8cm to 0.5cm, and had surgery to remove what remained at Wythenshaw­e Hospital in July.

She has now been told her cancer has gone. ‘I was, and I am, very lucky,’ she says. ‘The procedure to insert Magseed took 15 minutes a week before my surgery and it was pain-free.

‘Previously, I’d have had to go through the added trauma of having wires inserted on the day of surgery, which would have left me with more damage. As it is, I have no scar on my breast and only a small one under my arm where my lymph nodes were removed.

‘Cancer takes away your confidence, so anything which reduces the scarring and makes it easier for patients is so important.’

Eric Mayes, chief executive of Endomag, which developed Magseed, says: ‘It’s intuitivel­y right that it could reduce the recurrence of breast cancer if it accurately removes all of the tumour, but we don’t have any data yet. In theory it could be used in different tumours.’

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