Albuquerque Journal

Officials contend with virus mutation

Vaccine distributi­on challenge remains a pressing issue


WASHINGTON — Virus mutations that could accelerate the spread of COVID-19 and vaccine distributi­on challenges are two of the main issues facing the country as states work to get shots in arms, Biden administra­tion health officials told reporters Wednesday.

If the country continues on its current trajectory, the United States will report between 479,000 and 514,000 total COVID-19 deaths by Feb. 20, Centers for Disease Control and Prevention Director Rochelle Walensky said.

Though the Biden administra­tion promised Tuesday to increase states’ vaccine supply by 16% and said it would have 600 million doses available by the end of this summer, health officials warned that shots delivered does not necessaril­y correlate to shots in arms. Americans should be prepared to wait several months before getting inoculated, as distributi­on problems could slow the process, officials warned.

Meanwhile, the nation faces growing risks as the coronaviru­s’s new variants mutate rapidly.

The National Institutes of Health and the CDC are trying to stay ahead of the mutations by monitoring strains from the United Kingdom and South Africa, but Biden administra­tion officials said the agencies need more support from Congress.

The two approved vaccines, one by Pfizer and BioNTech and another by Moderna, both have enough of a cushion to protect against these two strains of the virus, said Dr. Anthony Fauci, the nation’s top infectious disease expert at the NIH. Still, scientists expect the coronaviru­s will continue to mutate.

The CDC and NIH are working with drug and vaccine makers to develop what they call boosts that would use the same platform as the vaccines and incorporat­e an immunogen that combats the new strain. To successful­ly do that, scientists need to stay a step or two ahead of the virus’ trajectory.

States are currently collecting virus strains, and scientists are conducting genomic surveillan­ce of the virus’ impact on the antibodies produced by the approved vaccines and vaccines currently under review.

But congressio­nal aid would provide more resources to detect new strains of the virus. The coronaviru­s relief package lawmakers are debating would include money to step up the sequencing effort and help scientists detect new strains when they first start to emerge, Walensky said.

Thus far, the U.K. variant has shown a very slight impact on vaccine-induced antibodies but nothing else, Fauci said, so that is not enough to diminish the vaccine’s effectiven­ess.

“Things may be a little more problemati­c” with the South African strain, Fauci said, because it weakens vaccineind­uced antibodies in multiple ways. So far, this isn’t enough of an effect to minimize the Moderna and Pfizer vaccines’ efficacy. But the situation may soon change.

“We have to be concerned looking forward to what the further evolution of this might be,” Fauci said.

The quick-spreading strain from the U.K. has already been discovered in several states, but the potentiall­y more dangerous South African strain is not known to be here yet.

Despite the concern about the mutations, Walensky cited “some hopeful signs” about the state of the pandemic, including that last week the seven-day average of new cases decreased by 21% and the rate of new hospital admissions due to COVID-19 decreased by 15%.

Still, the country faces a mounting death toll.

 ??  ?? Dr. Anthony Fauci
Dr. Anthony Fauci
 ??  ?? Rochelle Walensky
Rochelle Walensky

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