Baltimore Sun

US panel backs off advice on taking aspirin

Daily use does little to curb first stroke or heart attack, data says

- By Dennis Thompson

Most people shouldn’t bother taking daily low-dose aspirin to reduce their risk of a first heart attack or stroke, the nation’s leading panel of preventive medicine experts announced Tuesday.

The U.S. Preventive Services Task Force, or USPSTF, issued a draft recommenda­tion that essentiall­y backs off its previous advice urging many folks to consider taking low-dose aspirin to prevent heart disease.

If the proposal is adopted, the task force would recommend against low-dose aspirin use to prevent heart problems for people 60 and older.

The choice for people between 40 and 59 would be between themselves and their doctor, but the task force warns that the “net benefit of aspirin use in this group is small.”

“Persons who are not at increased risk for bleeding and are willing to take low-dose aspirin daily are more likely to benefit,” the draft recommenda­tion says.

The change reflects new data showing that daily aspirin does little to prevent a first heart attack or stroke, but greatly increases the risk of potentiall­y serious side effects like bleeding.

The proposal would not change guidelines for people taking aspirin to prevent a second heart attack.

“There’s no longer a blanket statement that everybody who’s at increased risk for heart disease, even though they never had a heart attack, should be on aspirin,” task force member Dr. Chien-Wen Tseng said. “We need to be smarter at matching primary prevention to the people who will benefit the most and have the least risk of harms.”

Tseng is research director of family medicine and community health at the University of Hawaii.

While aspirin is an effective blood thinner that can prevent blood clots from clogging arteries and causing a heart attack or stroke, heart experts have constantly weighed that benefit against the risk of internal bleeding.

New data suggest that “the increased risk of bleeding associated with aspirin use occurs relatively quickly after initiating aspirin,” with the absolute risk of bleeding increasing with age, the USPSTF says in its draft recommenda­tion.

A low dose is 81 milligrams to 100 milligrams.

One of the main goals of the proposed recommenda­tions, Tseng told The Washington Post, is “to get people to talk with their clinicians instead of just buying a bottle off the shelf and saying, ‘I should be on aspirin.’ ”

The USPSTF’s current advice regarding aspirin use in preventing heart disease was issued in 2016.

At that time, it recommende­d low-dose aspirin for 50- to 59-year-olds who had a 10% or greater risk of a heart attack or stroke over the next decade. These folks should also have no increased risk for bleeding, a life expectancy of at least 10 years, and be willing to keep up with their daily aspirin regimen. The current recommenda­tions say people between the ages of 60 and 69 have an individual choice to take aspirin if they have a 10% or higher risk of a potentiall­y fatal heart-related event within the next decade.

Dr. Donald Lloyd-Jones, president of the

American Heart Associatio­n, told the Post that the 2016 guidelines stemmed from clinical trial data collected in the 1980s and 1990s, “a time when we weren’t really focused on or doing a particular­ly good job of controllin­g things like blood pressure and cholestero­l, so aspirin had room to add value in preventing heart attacks and strokes.”

But aspirin’s benefit has become less crucial, thanks to better medication­s and healthier lifestyle options, Lloyd-Jones said.

Dr. Guy Mintz, director of cardiovasc­ular health and lipidology at the Sandra Bass Heart Hospital in Manhasset, New York, said lowering cholestero­l, controllin­g diabetes, weight loss and exercise and quitting smoking are essential. But advances in preventive care make aspirin unnecessar­y.

“Now, 30 years later, we have more tools in primary prevention of a heart attack and extensive data to support our approach,” he said, adding: “With all of these advances the need for aspirin in all patients has been negated.”

Dr. Lauren Block, an internist-researcher at Feinstein Institutes for Medical Research, also in Manhasset, New York, said the guidance is important because so many adults take aspirin even though they have never had a heart attack or stroke.

Block, who is not on the task force, recently switched one of her patients from aspirin to a cholestero­l-lowering statin drug because of the potential harms.

The patient, Richard Schrafel, 70, has high blood pressure and knows about his heart attack risks. Schrafel, president of a paperboard-distributi­on business, said he never had any ill effects from aspirin, but he is taking the new guidance seriously.

Public comment on the draft revision will be accepted through Nov. 8, the USPSTF said.

The USPSTF is made up of 16 experts in preventive medicine who regularly assess the scientific data supporting different screening tools and preventive treatments.

The task force is independen­t, although its members are appointed by the director of the federal Agency for Healthcare Research and Quality.

 ?? EMMA H. TOBIN/AP ?? A panel now says most people should not take aspirin daily to reduce the risk of a first heart attack or stroke.
EMMA H. TOBIN/AP A panel now says most people should not take aspirin daily to reduce the risk of a first heart attack or stroke.

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