The Saline Courier Weekend

Exploring treatments for excessive sweating

- ••• Eve Glazier, M.D., MBA, is an internist and associate professor of medicine at UCLA Health. Elizabeth Ko, M.D., is an internist and assistant professor of medicine at UCLA Health.

Dear Doctors: I’ve read your column for years but have yet to see anything about my problem. I tend to sweat a lot, not under my arms, but in my crotch area. It’s embarrassi­ng and even causes me to get a lot of UTIS. I’ve tried panty liners and medicated powders, wear only cotton underwear, but nothing works. I’m so frustrated. What can I do?

Dear Reader: Excessive sweating that isn’t a response to either heat or exertion is known as hyperhidro­sis. When sweat glands are overactive in one specific location, it’s referred to as focal hyperhidro­sis. The condition is believed to arise from overstimul­ation of the sweat glands by the autonomic nervous system, although why this occurs is unclear.

Excessive sweating in the armpits and around the head and face are the most common types of hyperhidro­sis. The folds of skin beneath the breasts are another area of focal hyperhidro­sis. Although less common, sweating in the area of the groin is a problem for many women. Researcher­s recently conducted a survey of close to 2,000 adults who are registered users of the Internatio­nal Hyperhidro­sis Society website, found at sweathelp.org. In that survey, 43% of respondent­s reported experienci­ng excessive sweating in the groin area.

Our bodies use sweat to stay cool. When certain physiologi­cal signals let the brain know the body is at risk of exceeding its optimal temperatur­e range, they direct the sweat glands to release moisture. This results in an evaporativ­e effect, which helps to cool the skin and regulate temperatur­e. And while sweating in the crotch area is a normal function of this cooling system, sometimes the signals go awry.

Some women find relief with topical antiperspi­rants. These use chemical compounds to temporaril­y plug the pores through which sweat exits and reduce the amount of moisture that is released. However, antiperspi­rants can be irritating to delicate skin and tissues, and they should be kept away from the vagina.

Two therapeuti­cs, which have been approved by the U.S. Food and Drug Administra­tion for excessive underarm sweating, are finding off-label use in other types of focal hyperhidro­sis. One, a prescripti­on medication called Qbrexza, is a premoisten­ed towelette saturated with a medication. It is applied once daily to the affected skin. Also approved for excessive underarm sweating is Botulinum toxin A, more widely known as Botox.

Some physicians are reporting success with offlabel uses of these medication­s, including for hyperhidro­sis in the crotch area. However, it’s important to understand that neither of these medication­s are Fda-approved for hyperhidro­sis in any region other than the underarms. When it comes to Botox, the amount of the drug required for the crotch area can make the treatment quite costly. It’s also very important that the physician providing the treatment is well-versed in the specific injection strategies that are being pioneered.

If you haven’t already, please consult with your health care provider. They can help you with strategies to lessen the incidence of UTIS and other infections. They can also offer guidance if you choose to pursue other options.

“Congress shall make no law ... abridging the freedom of speech, or of the press ... .” — From the First Amendment to Constituti­on

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DR. GLAZIER

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