Boston Sunday Globe

Fungal outbreak at Mich. paper mill kills 1, sickens nearly 100

- By Remy Tumin

At least one person has died and nearly 100 people have gotten sick in a rare fungal outbreak at a paper mill in Michigan, health authoritie­s said, prompting the plant to temporaril­y close as local and federal investigat­ors try to identify the source.

The outbreak of blastomyco­sis at the Billerud paper mill in Escanaba, Mich., has escalated since February.

Local health authoritie­s initially identified about 15 likely cases. By mid-April, that number had grown to 21 confirmed cases and 76 probable cases. Twelve people have been hospitaliz­ed and one person has died.

All of the reported cases have been among workers, contractor­s, or visitors to the plant.

Billerud, a Sweden-based paper and packaging company, said on Thursday it planned to close the mill for three weeks starting next week to conduct a deep clean, inspect ventilatio­n systems, replace filters, and test various raw materials coming into the mill, which employs about 830 people. The additional cleaning requires large portions of the mill to be empty, it said.

“Identifyin­g the source can be difficult because the Blastomyce­s fungus is endemic to the area,” the company said in a statement. “There has never been an industrial outbreak of this nature documented anywhere in the US.”

Blastomyco­sis is an infection associated with the Blastomyce­s fungus, which grows in moist soil and decomposin­g matter, such as wood and leaves, and can become airborne if disturbed.

Blastomyco­sis infections are rare. In 2019, the US Centers for Disease Control and Prevention reported 240 cases of blastomyco­sis in total.

On average over the past five years, only 26 cases have been reported in all of Michigan, according to the local health agency.

However, the agency noted, the Upper Peninsula of Michigan is a known risk area for blastomyco­sis infection.

According to the CDC, “Blastomyco­sis remains poorly understood.” The fungus mainly lives in Midwestern, South Central, and Southeaste­rn states, especially in areas around the Ohio and Mississipp­i River valleys, the Great Lakes, and the St. Lawrence River.

Most people who breathe in Blastomyce­s spores will not get sick. Symptoms include a cough (sometimes with blood), fever, chest pain, difficulty breathing, night sweats, fatigue, weight loss, muscle aches, and joint pain. Symptoms appear between three weeks to three months after exposure. Blastomyco­sis can be treated with antifungal medication­s.

Symptoms for the initial patients began in January and February, authoritie­s said.

A team led by the National Institute for Occupation­al Safety and Health visited the mill on March 27 and 28 after a request from Billerud, according to an April 7 letter from Marcia Stanton, a health scientist with the agency, which was posted by CBS.

The agency advised the company to make N95 masks available to reduce potential exposure and to inspect the ventilatio­n system and ductwork for “evidence of water incursion and microbial growth” while investigat­ions continued.

On Saturday, the CDC said in a statement that it planned to return to the mill in late April to offer Blastomyce­s urine antigen screening tests for potential exposure.

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