Chicago Tribune (Sunday)

Vaccines made in China not effective

Countries relying on those shots see spike in infections

- By Sui-Lee Wee

Mongolia promised its people a “COVID-free summer.” Bahrain said there would be a “return to normal life.” The tiny island nation of the Seychelles aimed to jump-start its economy.

All three put their faith, at least in part, in easily accessible Chinese-made vaccines, which would allow them to roll out ambitious inoculatio­n programs at a time when much of the world was going without.

But instead of freedom from the coronaviru­s, all three countries are now battling a surge in infections.

China kicked off its vaccine diplomacy campaign last year by pledging to provide a shot that would be safe and effective at preventing severe cases of COVID-19. Less certain at the time was how successful it and other vaccines would be at curbing transmissi­on.

Now, examples from several countries suggest the Chinese vaccines may not be very effective at preventing the spread of the virus, particular­ly the new variants. The experience­s of those countries lay bare a harsh reality facing a post-pandemic world: The degree of recovery may depend on which vaccines government­s give to their people.

In the Seychelles, Chile, Bahrain and Mongolia, 50% to 68% of the population­s have been fully inoculated, outpacing the United States, according to Our World in Data, a data tracking project. All four ranked among the top 10 countries with the worst COVID outbreaks as recently as last week, according to data from The New York Times. And all four are mostly using shots made by Chinese vaccine makers Sinopharm and Sinovac Biotech.

“If the vaccines are sufficient­ly good, we should not see this pattern,” said Jin Dongyan, a virus expert at the University of Hong Kong.

Scientists don’t know for certain why some countries with relatively high inoculatio­n rates are suffering new outbreaks. Variants, social controls that are eased too quickly and careless behavior after only the first of a two-shot regimen are possibilit­ies. But the breakthrou­gh infections could have lasting consequenc­es.

In the United States, about 45% of the population is fully vaccinated, mostly with doses made by PfizerBioN­Tech and Moderna. Cases have dropped 94% over six months.

Israel provided shots from Pfizer and has the second-highest vaccinatio­n rate in the world, after the Seychelles. The number of new daily confirmed COVID-19 cases in Israel is now around 4.95 per million.

In the Seychelles, which relied mostly on Sinopharm, that number is more than 716 cases per million.

Disparitie­s such as these could create a world in which three types of countries emerge from the pandemic — the wealthy nations that used their resources to secure PfizerBioN­Tech and Moderna shots, the poorer countries that are far away from immunizing a majority of citizens, and then those that are fully inoculated but only partly protected.

China, as well as the more than 90 nations that have received the Chinese shots, may end up in the third group, contending with rolling lockdowns, testing and limits on day-to-day life for months or years to come.

Economies could remain held back. And as more citizens question the efficacy of Chinese doses, persuading unvaccinat­ed people to line up for shots may also become more difficult.

One month after receiving his second dose of Sinopharm, Otgonjarga­l Baatar fell ill and tested positive for COVID-19. The 31-year-old miner spent nine days in a hospital in Ulaanbaata­r, the capital of Mongolia. He said he was now questionin­g the usefulness of the shot.

“People were convinced that if we were vaccinated, the summer will be free of COVID,” he said. “Now it turns out that it’s not true.”

Beijing saw its vaccine diplomacy as an opportunit­y to emerge from the pandemic as a more influentia­l global power. China’s top leader, Xi Jinping, pledged to deliver a Chinese shot that could be easily stored and transporte­d to millions of people around the world.

Xi called it a “global public good.”

Mongolia was a beneficiar­y, jumping at the chance to score millions of Sinopharm shots. The small country quickly rolled out an inoculatio­n program and eased restrictio­ns. It has now vaccinated 52% of its population. But on June 20, it recorded 2,400 new infections, a quadruplin­g from a month before.

In a statement, China’s Foreign Ministry said it did not see a link between the recent outbreaks and its vaccines. It cited the World Health Organizati­on as saying that vaccinatio­n rates in certain countries had not reached sufficient levels to prevent future outbreaks, and that countries needed to continue to maintain controls.

“Relevant reports and data also show that many countries that use Chinese-made vaccines have expressed that they are safe and reliable, the ministry said.

No vaccine fully prevents transmissi­on and people can still fall ill after being inoculated, but the relatively low efficacy rates of Chinese shots have been identified as a possible cause of the recent outbreaks.

Pfizer-BioNTech and Moderna have efficacy rates of more than 90%. Other vaccines — including AstraZenec­a and Johnson & Johnson — have efficacy rates of around 70%. The Sinopharm vaccine developed with the Beijing Institute of Biological Products has an efficacy rate of 78.1%; the Sinovac vaccine has an efficacy rate of 51%.

The Chinese companies have not released much data to show how their vaccines work at preventing transmissi­on. On Monday, Shao Yiming, a public health researcher with the Chinese Center for Disease Control and Prevention, said China needed to fully vaccinate 80% to 85% of its population to achieve herd immunity, revising a previous official estimate of 70%.

Data on breakthrou­gh infections have not been made available either, though a Sinovac study out of Chile showed that the vaccine was less effective than those from PfizerBioN­Tech and Moderna at preventing infection among vaccinated individual­s.

A representa­tive from Sinopharm hung up when reached for comment. Sinovac did not respond to a request for comment.

William Schaffner, medical director of the National Foundation for Infectious Diseases at Vanderbilt University, said the efficacy rates of Chinese shots could be low enough “to sustain some transmissi­on, as well as create illness of a substantia­l amount in the highly vaccinated population, even though it keeps people largely out of the hospital.”

Despite the spike in cases, officials in both the Seychelles and Mongolia have defended Sinopharm, saying it is effective in preventing severe cases of the disease.

 ?? KHASAR SANDAG/THE NEW YORK TIMES ?? Pedestrian­s in Ulaanbaata­r, Mongolia on May 12. Chinese-made vaccines had Mongolia promising its citizens a “COVID-free summer.” However, on June 20, the country recorded 2,400 new infections.
KHASAR SANDAG/THE NEW YORK TIMES Pedestrian­s in Ulaanbaata­r, Mongolia on May 12. Chinese-made vaccines had Mongolia promising its citizens a “COVID-free summer.” However, on June 20, the country recorded 2,400 new infections.

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