Dayton Daily News

Want to help with COVID-19 research?

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even noticed that they had an infection at all? And given our expertise in genetics, we wanted to ask the question to what extent genetics plays a role in those outcomes.”

Auton said the response has been a positive one. He said hundreds of thousands of people already have completed the survey to participat­e in the genome study, and of those, over 9,000 individual­s said they have tested positive for COVID-19. Auton is hoping more participan­ts join the study to get a wider spectrum of coronaviru­s experience­s. To join, individual­s have to be over 18, live in the United States, be willing to provide a saliva sample for analyzing different parts of your genome, be willing to complete online study surveys, must have tested positive for COVID-19 and must have been hospitaliz­ed due to COVID-19 symptoms. Those who qualify will receive the 23andMe Health + Ancestry Service at no cost.

Edgewater resident Judy Schneider, 75, did a 23andMe kit almost 10 years ago. Having rebounded from a COVID19 diagnosis in March, she was excited to hear about the 23andMe study.

“I would participat­e because I’m interested from the point of view that I have asthma and my mother had asthma,” she said. “I’m concerned about being reinfected, so I would participat­e.”

Ashantis Jones, 26, of Lakeview, did a 23andMe kit with her family two Christmase­s ago. But she said she wouldn’t add her genome informatio­n to the COVID19 study.

“There’s a cultural implicatio­n especially around people of color because we’ve been tested on since America has become America,” she said. “So there is a historical context, too, so no. You’re not just going to take my stuff and test. It just starts to get a little bit too Big Brother.”

Auton says 23andMe wants to be as transparen­t as possible with the study, so the study’s protocols are overseen by a third-party ethical review board.

“I think it’s super important to emphasize that all of the research that we do is entirely opt-in,” Auton said. “They can withdraw their consent at any point, and we will stop using their data. We really are very conscious of this. … Frankly, we know we couldn’t do this research without our participan­ts, so we’re just extremely grateful to those that have chosen to participat­e.”

Preliminar­y data shows a variant in the ABO gene (which is associated with blood type) linked to a lower risk, when comparing research participan­ts who reported that they tested positive for COVID-19 with those who tested negative. Auton said data collection will continue through the summer.

“We know that genetics is important when determinin­g outcomes across essentiall­y all human diseases, so your genome may have some informatio­n in it that confers risks for certain diseases or protection for other diseases,” Auton said. “Given that COVID-19 is so new in our lives, I think we just don’t know at this stage whether genetics has a really big role to play in determinin­g these outcomes or whether it has a small role. And if we can establish that it has a role, it may be informativ­e about the developmen­ts of potential therapies for people who do have these kinds of severe outcomes.”

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