TV HIGHLIGHTS

Station 19, 8 PM on Ch. 22 and Ch. 9: The “Grey’s Anatomy” spinoff opens Season 4 with “Nothing Seems the Same,” a title that, in part, refers to how these gallant first responders are trying to adjust to the challenging new reality of the COVID-19 pandemic, which complicates their efforts to render critical assistance to victims in a timely manner. Elsewhere, Andy (Jaina Lee Ortiz) is still reeling to learn her mother, long presumed dead, is alive. The episode also kicks off a heavily promoted three-hour crossover event with “Grey’s Anatomy,” which immediately follows.

Supernatural, 8 PM on Ch. 26: The 15th and final season races closer to its (probably) apocalyptic conclusion in the penultimate episode “Inherit the Earth,” which finds virtually everything on the line — heaven, hell and the human world in between — as Sam and Dean (Jared Padalecki, Jensen Ackles) continue their high-stakes battle against God (guest star Rob Benedict). Meanwhile, a familiar face returns to join the fight.

Grey’s Anatomy, 9 PM on Ch. 22 and Ch. 9: Season 17 opens with a two-hour episode that picks up with a slight time jump from the end of Season 16, which had to shut down prematurely due to the coronavirus outbreak. As the action resumes, the pandemic has been raging for a couple of months, and the doctors already are taxed to their limits. The real-life crisis posed challenges off-screen as well, with new camera lenses used to make actors look as if they’re standing closer than they really are. Ellen Pompeo and Chandra Wilson return.