Common medications can prolong back pain
The very treatments often used to soothe pain in the lower back, which the Centers for Disease Control and Prevention says is the most common type of pain, might cause it to last longer, according to a new study.
Persistent use of pain-relieving steroids and nonsteroidal anti-inflammatory drugs, like ibuprofen, can actually turn a wrenched back into a chronic condition, the study found.
Some medical experts urged caution in interpreting the results too broadly. The study did not use the gold standard for medical research, which would be a clinical trial in which people with back pain would be randomly assigned to take a nonsteroidal anti-inflammatory drug or a placebo and followed to see who developed chronic pain.
Instead, it involved observations of patients, an animal study, and an analysis of patients in a large database.
“It’s intriguing but requires further study,” said Dr. Steven J. Atlas, director of primary care practice-based research and quality improvement at Massachusetts General Hospital.
Dr. Bruce M. Vrooman, a pain specialist at Dartmouth Hitchcock Medical Center in New Hampshire, agreed, but also called the study “impressive in its scope” and said that if the results hold up in a clinical trial, it could “force reconsideration of how we treat acute pain.”
Dr. Thomas Buchheit, director of the regenerative pain therapies program at Duke, had a different view.
“People overuse the term ‘paradigm shift’, but this is absolutely a paradigm shift,” Buchheit said. “There is this unspoken rule: If it hurts, take an anti-inflammatory, and if it still hurts, put a steroid on it.” But, he said, the study shows that “we have to think of healing and not suppression of inflammation.”
Guidelines from professional medical societies already say that people with back pain should start with nondrug treatments like exercise, physical therapy, heat or massage.
Those measures turn out to be as effective as pain-suppressing drugs, without the same side effects.
If the pain persists, the guidelines say, people can try nonsteroidal anti-inflammatory drugs like ibuprofen. (Acetaminophen is not an anti-inflammatory because it does not block inflammation.)
But the study, published last week in the journal Science Translational Medicine, included a warning that such drug treatment advice could contribute to chronic pain that would lower a person’s quality of life.
The study began when researchers at McGill University started searching for molecular markers in the blood that would predict which patients would
have pain that quickly diminished and which would have pain that persisted.
The group had blood samples from 98 people taken when they first reported developing back pain and again three months after their pain began.
“What we saw wasn’t exactly what we expected,” said Dr. Luda Diatchenko, the study’s principal investigator and a professor at McGill who specializes in human pain genetics.
Those who said their pain went away had rapid and intense inflammation when the pain was acute.
The markers of inflammation then diminished over the next three months. Those whose pain persisted did not have such an inflammatory reaction.
“Absolutely nothing was happening” in those with chronic pain, Diatchenko said.“It was a huge difference.”
The researchers continued to investigate. They studied people with a different type of pain, TMJ, or temporomandibular joint disorders, which result in jaw pain.
Once again, those who recovered had rapid and intense inflammatory responses.
“We need to think further about how to treat our patients,” Diatchenko said.