GE­NETIC OB­STA­CLES TO HEAL­ING

EQUUS - - Eq Casereport -

There’s one fac­tor that Derek Knot­ten­belt, BVM&S, PhD, doesn’t al­ways in­clude on his fa­mous list of wound-heal­ing in­hibitors be­cause it’s rel­a­tively rare: ge­netic dis­ease.

“There are a few ge­netic ab­nor­mal­i­ties that can af­fect the phys­i­ol­ogy of the skin it­self and its abil­ity to heal,” Knot­ten­belt ex­plains. “In stock horses there’s HERDA [hered­i­tary equine re­gional der­mal as­the­nia] and there’s a sim­i­lar syn­drome in other breeds called epi­der­mol­y­sis bul­losa.” Both dis­eases pro­duce de­fects in the struc­ture of the skin that make it ex­tremely frag­ile and slow or un­able to heal. Car­ing for these horses can be dif­fi­cult, with or with­out wounds, and re­quires spe­cial­ized, in­tense man­age­ment. Many horses are eu­tha­na­tized be­cause the con­di­tion can­not be con­trolled.

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